Abstract: Abstract Objective To investigate effects of hemoperfusion on cholinesterase activity and inflammatory mediators in patients with severe acute organic phosphorus poisoning. Methods Cholinesterase activity, recovering time of cholinesterase, APACHEⅡ scores, inflammatory mediators, hospitalization time, cumulative dosage of atropine, mortality rate were measured in 55 patients treated with routine treatment (control group) and 55 patients treatd with hemoperfusion based on routine treatment (hemoperfusion group). Results Compared with control group, , APACHEⅡ scores, recovering time of cholinesterase, hospitalization time, cumulative dosage of atropine, mortality rate in hemoperfusion group were significantly reduced(P all <0.05), while cholinesterase activity in hemoperfusion group were significantly increased in the third day after hemoperfusion treatment (P<0.05). Serum tumor necrosis factor-α( TNF-α), interleukin-6, high-sensitivity C-reactive protein (hs-CRP) of patients in hemoperfusion group were significantly reduced after 3 days with hemoperfusion (P all <0.01). Conclusions Early hemoperfusion may improve prognosis via reducing inflammatory mediators in patients with severe acute organic phosphorus poisoning.

Key words: Hemoperfusion, Organic phosphorus poisoning, Inflammatory mediators, Cholinesterase