Abstract: Abstract：Objective To study the hypercoagulation state in nephrotic syndrome of pregnancy . Methods Coagulation and hemorrheology indexes were tested and analyzed contrastivly between 63 patients of nephrotic syndrome of pregnancy and 201 patients of severe pre-eclampsia. Results Compared with patients of severe pre-eclampsia,prothrombin time（PT）and activated partialthromboplastin time（APTT）were longer,D-dimer (D-D)and fibrinogen (FIB)were lower and antithrombin Ⅲ(AT-Ⅲ) increased,and blood viscosity(ηb)、plasma specific viscosity (ηp)、whole blood reduced viscosity (ηr)、hematocrit (HCT)、erythrocyte aggregation index (VAI)and thrombosis index(TFL)increased，erythrocyte deformability index(DI) decreased in patients of nephrotic syndrome of pregnancy.The differents were significant（P<0.05）.Conclusion The hypercoagulation state of nephrotic syndrome of pregnancy was more severer than commonly pre-eclampsia.

Key words: Nephrotic syndrome of pregnancy, Severe pre-eclampsia, Hypercoagulation, Hemorrheology