Abstract: Abstract Objective: To investigate the clinical characteristics and countermeasures of ectopic pregnancy (EP) after assisted reproductive technology (ART), deepen the understanding of complications of ART and reduce the misdiagnosis or missed diagnosis of EP after ART. Methods: The types, high risk factors and surgical treatment options were studied in 49 cases of EP after ART in Assisted Reproduction Center of our hospital during the past 12 years. Results: The tubal pregnancy is the most common type of EP after ART. The simple tubal pregnancy and tubal pregnancy in heterotopic pregnancy (HP) cases account for about 85.71% of the total number. Other types included cornual pregnancy, ovarian pregnancy and abdominal pregnancy. The high risk factors of EP after ART included tubal factors, endometriosis, EP surgery and other gynecological surgery history, abortion history, uterine factors. And the difference of above high risk factors was significantly significant (X2 = 34.8, P <0.001). Tubal factors were accounted for a percentage of 42.86%, which was the main factor for EP after ART. Patients with tubal pregnancy were performed laparoscopic ipsilateral or bilateral salpingectomy. Patients with cornual pregnancy, based on fetal sac location, were performed either aspiration of uterus by laparoscopy combined with abdominal ultrasound or laparoscopic cornual patial resection. There were no persistent ectopic pregnancy in 49 postoperative patients. The clinical cure rate was 100%. Conclusion: The tubal factor is one of the most important risk factors induced EP after ART. The salpingectomy is recommended before ART for infertility patients caused by tubal factors to reduce the probability of ectopic pregnancy. Doctors should communicate with patients before ART and make them mentally prepared, in order to promote early detection and timely treatment for EP. Patients should have surgical treatment immediately to remove the EP lesions, and also strive to continue the intrauterine pregnancy.

Key words: assisted reproductive technology, ectopic pregnancy, heterotopic pregnancy, high risk factor, surgical treatment