Abstract: 【Abstact】: Objective To investigate the effect of preoperative parecoxib(40mg) on end-tidal concentration of sevoflurane during craniotomy and anesthetic recovery. Methods 137 neurosugical patients , ASA physical I～II , were randomly allocated into two groups to receive paracoxib 40mg ( Group P，n=72) , placebo ( Group C，n=65) . The end-tidal concentration of sevoflurane was measured. The volumes of bleeding , transfusion , fluid infusion and urine were recorded. The time of consciousness , psychomotor and cognitive recoveries from general anesthesia, and complication in recovery after anaesthesia were observed. Results The end-tidal concentration of sevoflurane in group P were reduced 6% at the time of hemostasis,sewing dura matter, sewing skin(P<0.05),and 10%, 12%,7%( P < 0.01) at the time of sawing bone and cutting dura matter，intracalvarium operating(p<0.01) compared to the group C .No different between the groups in the volume of infusion,fluid loss,bleeding and urine. The recovery time of conscious , psychomotor and cognitive from general anesthesia were reduced by 22%,27% and 23% respectively compared to group C( P < 0.01 ) . The incidence of hypertension(16.7%) and the incidence of shivering(2.8%) in the group P were significantlylower than that in group C(38.5% for hypentension and 12.3% for shivering) .there were no difference in the incidence of restlessness and arrhythmia. Conclusion The preoperative application of parecoxib(40mg) can reduce the end-tidal concentration of sevoflurane, smooth the recovery from anesthesia.

Key words: parecoxib, craniotomy, sevoflurane