Abstract: Abstract   Objective    To Investigate the role of Plasma apolipoprotein A1 (ApoA1)/apolipoprotein (ApoB) and other lipid parameters in the occurrence and development of coronary heart disease. Method    In the Year 2010-2011, 550 cases underwent coronary angiography (CAG) in Tianjin Chest Hospital, were divided into coronary heart disease group and normal group according to the result of CAG. Coronary Heart Disease Group includes single-vessel disease group, double vessel disease group, and three vessel disease group. Plasma apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and apolipoprotein ApoA1/ApoB (ApoA1 / B) were measured and analyzed respectively in all groups. Results    The value of ApoA1/ApoB in coronary artery disease was statistically significant (P<0.01); Multivariate Logistic regression analysis confirmed that the ApoA1 /Apo B was protective factors for coronary atherosclerosis (P＜0.01). Conclusion    The value of ApoA1/ApoB has meaningful relation in diagnosis and treatment of different degree of coronary atherosclerosis in comparison with other relative lipid factors.

Key words: Coronary artery disease, cholesterol ester transfer proteins, cholesterol, HDL, apolipoprotein A-Ⅰ, risk factors, statistics, 非参数