Abstract: Dendritic cells (DCs) are potent antigen presenting cells with dual functions in immune response or immune tolerance. Regulatory dendritic cells (DCreg) have negative immunomodulation effects. They can inhibit T cell stimulatory activity and induce immune tolerance. DCreg could be generated by the induction of drugs, cytokines and cell microenvironment with different mechanisms. The tolerance that DCreg induced is of great clinical significance in organ transplantation and autoimmune disease. Recently, several clinical trials have been conducted in type 1 diabetes and rheumatoid arthritis, with results that emphasize the tolerance and safety of DCreg therapy. In this review, we will focus on the strategies for generating DCreg and the clinical application of immune tolerance.

Key words: Immune tolerance, Organ transplantation, Diabetes mellitus, type 1, Arthritis, rheumatoid, T-lymphocytes, 调节性树突状细胞