Abstract: Objective To investigate the correlation of left ventricular ejection fraction (LVEF) as well as serum levels of NT-proBNP, Hcy and D-Dimer (D-D) with different traditional Chinese medicine (TCM) syndrome types of chronic heart failure (CHF). Methods A total of 178 CHF patients were divided into heart function normal ejection fracture group (HFNEF, n=86) and heart function reduction (HFREF, n=92) according to their LVEF performance. Another 35 cases with normal cardiac function were included in control group. All CHF patients was also divided into 3 TCM syndrome types: "both deficiency of Qi and Yin syndrome group" (n=64), "Qi asthenia causing blood stasis syndrome group" (n=59) and "Yang deficiency water stop group" (n=55). All patients were examined with cardiac color doppler and LVEF values were recorded.And serum NT-proBNP、 Hcyand D-D levels were all quantified. Results As to serum levels of NT-proBNP, Hcy and DD, they were higher in HFREF group than those in HFNEF group than those in control group. On the other hand, LVEF was
lowest in HFREF group but highest in control group. All differences were statistically significant (P < 0.05). Among patient in HFNEF group, LVEF in the "Yang deficiency water stop group" was lower than that in "both deficiency of Qi and Yin syndrome group" (P < 0.05). Serum levels of NT-proBNP, Hcy, and D-D were not significantly different between different TCM syndrome groups. By contrast, among patients in HFREF group, LVEF values did not differ significantly between different TCM syndrome groups. Serum level of NT-proBNP was lower in "both deficiency of Qi and Yin syndrome group" than that in Hcy and D-D, they are higher in "Yang deficiency water stop group" that those in "both deficiency of Qi and Yin syndrome（P＜0.05). Conclusion Patients with different TCM syndrome types of CHF present different levels of serum NT-proBNP, Hcy, D-D level and LVEF. Changes of indicators in HFREF groups are more obvious than they did in HFNEF group.

Key words: heart failure, stroke volume, natriuretic peptide,brain, traditional Chinese medicine syndrome types,
LVEF, NT-proBNP, Hcy, D-dimer