Abstract: Abstract： Objective To study the clinicopathologic features of brain tumors in patients with medically intractable lepsy. Methods The clinical, radiologic and pathologic features of brain tumors in thirty-six patients with intractable lepsy encountered during the period from 2008 to 2014 in the Epilepsy Center of Haidian Hospital were retrospectively iewed. Results There were 18 males and 18 females in thirty-six patients. The mean age of seizure onset and disease ation were (14.05 ± 1.67) years and (10.04 ± 1.19) years respectively. The histological types of brain tumors included glioglioma (12/36, WHO gradeⅠ， 1/36, WHO gradeⅡ), dysembryeplastic neuroepithelial tumor (2/36, WHO grade Ⅰ), omorphic xanthoastrocytoma (1/36, WHO grade Ⅱ), angiocentric glioma (1/36, WHO gradeⅠ), astrocytoma (4/36, WHO de Ⅱ), oligoastrocytoma (1/36, WHO grade Ⅱ, 2/36, WHO grade Ⅰ-Ⅱ), oligodendroglioma (1/36, WHO gradeⅠ-Ⅱ， 1/36, HO grade Ⅱ), cavernous hemangioma (4/36) and Sturge-Weber syndrome (1/36). Most of these tumors were located intemporal lobe (25/36, 69.4%). Patients were followed up for 0.5-7 years after operation. One patient was lost for follow up. Seizure outcome after the epilepsy operation revealed that 28 patients (77.8%) had Engel gradeⅠ, 4 patients (11.1%) had Engel gradeⅡ， 2 patients (5.6%) had Engel grade Ⅲ， 1 patient (2.8%) had Engel grade Ⅳ. Conclusion Brain tumors in patients with medically intractable epilepsy are almost low grade tumors of the nervous system. Focal cortical dysplasia is existed in most brain tissues from the epilepsy operation. Low grade tumors of the nervous system have close relation with focal cortical dysplasia in patients with medically intractable epilepsy. It is possible that the classifications of pathology diagnosis has connection with prognosis.

Key words: epilepsy, neurosurgical procedures, brain neoplasms, malformations of cortical development