Abstract: Abstract: Objective To investigate the relationship between advanced fibrosis and peripheral neuropathy in patients with type 2 diabetes mellitus (T2DM). Methods Select 173 patients (88 men and 85 women) with type 2 diabetes who hospitalized in tianjin third central hospital within nearly three years（2013.02-2015.02）and divide the participants into 3 groups according to NAFLD fibrosis score: group A (Low NFS，NFS≤—1.455), group B (Intermediate NFS，—1.455＜NFS＜0.676) and group C (High NFS，NFS≥0.676). Compare the prevalence of DPN between three groups. Diabetic neuropathy was ascertained by electroneurogram and liver fibrosis severity was ascertained by NAFLD fibrosis score. Results The prevalence of DPN in group A, group B and group C was 69.4%, 78.9% 86.2%, respectively. The prevalence of DPN was significantly higher in group C compared with group A (OR=5.96, P=0.014); there was no significant statistical difference between group B and group A (OR=1.76, P=0.155) in spite of that the prevalence of DPN was higher in group B than group A. Moreover, the prevalence of SNCA and MNCA were significantly higher in group C than group A (OR=6.50 vs 5.96, all P＜0.05). After adjustment for confounding factors, such as age, diabetic duration, HOMA-IR, serum lipid level, liver function and inflammatory factors, advanced fibrosis remained significantly associated with a higher odds ratio of DPN and MNCA(OR=2.16 vs 2.28, all P＜0.05), but no longer with SNCA(OR=1.88，P=0.087). Conclusion Advanced fibrosis has a close relationship with diabetic neuropathy, especially with motor nerve conduction abnormalities.

Key words: Type 2 diabetes mellitus, Non-alcoholic fatty liver disease, Advanced fibrosis, Liver fat content, Diabetic neuropathy