天津医药

天津医药 ›› 2017, Vol. 45 ›› Issue (1): 68-71.doi: 10.11958/20160489

• 临床研究 • 上一篇    下一篇

中性粒细胞与淋巴细胞比值在绝经后 2 型糖尿病 患者中的临床价值

彭奕贤， 杨银， 李文高， 吴智勇， 罗鹏， 唐如， 何雷△   

  1. 广州， 南方医科大学珠江医院内分泌科 （邮编 510282）
  • 收稿日期:2016-06-30 修回日期:2016-11-25 出版日期:2017-01-15 发布日期:2017-01-15
  • 通讯作者: 何雷 E-mail:765139701@qq.com

The clinical value of neutrophil to lymphocyte ratio in postmenopausal patients with type 2 diabetes

PENG Yi-xian, YANG Yin, LI Wen-gao, WU Zhi-yong, LUO Peng, TANG Ru, HE Lei△   

  1. Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
  • Received:2016-06-30 Revised:2016-11-25 Published:2017-01-15 Online:2017-01-15

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摘要： 摘要： 目的 探讨中性粒细胞与淋巴细胞比值（NLR）在绝经后 2 型糖尿病（T2DM）患者中的临床价值。方法 选取 2015 年 3 月—9 月间南方医科大学珠江医院收治的新诊断为 T2DM 的女性患者 128 例， 按照生理状态分为绝 经组 （66 例） 和未绝经组 （62 例）， 另取 56 例体检健康女性作为对照组。检测 3 组血压、 血脂、 空腹血糖 （FPG）、 空腹 胰岛素（FINS）、 各外周血白细胞总数（WBC）、 中性粒细胞数绝对值、 中性粒细胞百分比、 淋巴细胞数、 淋巴细胞百分 比等指标， 计算 NLR， 稳态模型胰岛素抵抗指数（HOMA-IR）。结果 绝经组年龄、 收缩压（SBP）、 三酰甘油（TG）、 FINS、 中性粒细胞百分比、 NLR、 HOMA-IR 均高于未绝经组和对照组（P < 0.05）。绝经组和未绝经组舒张压（DBP）、 FPG 比较差异无统计学意义， 但均高于对照组（P < 0.05）； 而 3 组间总胆固醇（TC）、 高密度脂蛋白胆固醇（HDL-C）、 低密度脂蛋白胆固醇（LDL-C）、 WBC、 糖化血红蛋白（HbA1c）等指标比较差异无统计学意义（P > 0.05）。NLR 与 HOMA-IR（rs=0.015）、 HbA1c （r=0.030） 无线性相关关系 （均 P > 0.05）。结论 NLR 对绝经期 T2DM 患者的炎症状态 及胰岛素抵抗 （IR） 水平有一定评估意义， 这可能与自主神经改变有关。

关键词: 糖尿病, 2 型, 胰岛素抵抗, 绝经后期, 自主神经系统, 中性粒细胞淋巴细胞比值

Abstract: Abstract：Objective To investigate the clinical value of neutrophil- lymphocyte ratio (NLR) in postmenopausal patients with type 2 diabetes mellitus (T2DM). Methods A total of 128 newly diagnosed T2DM female patients were randomly recruited from the Zhujiang Hospital of Southern Medical University from March to September 2015. According to the physiological state, the patients were divided into menopausal group (n=66) and non- menopausal group (n=62). Fiftysix healthy females were chosen as the control group. The values of blood pressure, blood lipid, fasting plasma glucose (FPG), fasting insulin (FINS) and white blood count (WBC), neutrophil count, percentage of neutrophils， lymphocytes count, and percentage of lymphocytes were detected and compared between three groups. The NLR and the HOMA insulin resistance index (HOMA- IR) were calculated. Results Age, systolic blood pressure (SBP), triglyceride (TG), FINS, percentage of neutrophil, NLR, HOMA-IR were significantly higher in menopause group than those of control group and non-menopause group (P < 0.05). There were no significant differences in diastolic blood pressure (DBP) and FPG between menopause group and non- menopause group, but both were significantly higher than those of control group (P < 0.05). There were no significant differences in total cholesterol (TC), high density lipoprotein cholesterol (HDL- C), low density lipoprotein cholesterol (LDL-C), WBC and HbA1c between three groups (P > 0.05). There was no linear correlation between NLR and HOMA- IR (rs=0.015, P > 0.05), HbA1c (r=0.030, P > 0.05). Conclusion NLR is of a certain significance in the assessment of inflammatory status and IR levels in postmenopausal women with T2DM, which may be related to the changes of autonomic nervous system.

Key words: diabetes mellitus, type 2, insulin resistance, postmenopause;autonomic nervous system, neutrophil- tolymphocyte ratio