天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (11): 1384-1386.doi: 10.11958/20160696

• 诊断技术 • 上一篇    下一篇

142 例亚临床型生殖器疱疹患者病毒脱排特点分析

张婧 1， 黄熙 1， 蒙坚 1， 王利平 2， 魏娇 1， 蒋冬香 1， 程培华 1△   

  1. 1 桂林医学院附属医院皮肤性病科 （邮编 541001）； 2 柳州市人民医院
  • 收稿日期:2016-07-19 修回日期:2016-09-22 出版日期:2016-11-15 发布日期:2016-11-15
  • 通讯作者: △通讯作者 E-mail： phchengg@163.com E-mail:meganjing@126.com
  • 作者简介:张婧 （1990）， 女， 硕士在读， 主要从事生殖器疱疹研究
  • 基金资助:
    广西桂林市科技局攻关项目 （2013012010）； 广西自然科学基金资助项目 （2013GXNSFAA019206）

The characteristics of herpes simplex virus shedding in 142 cases of subclinical genital herpes

ZHANG Jing1, HUANG Xi1, MENG Jian1, WANG Liping2, WEI Jiao1, JIANG Dongxiang1, CHENG Peihua1Δ   

  1. 1 Department of Dermatovenereology, the Affiliated Hospital of Guilin Medical University, Guilin 541001, China; 2 Liuzhou General Hospital
  • Received:2016-07-19 Revised:2016-09-22 Published:2016-11-15 Online:2016-11-15
  • Contact: △Corresponding Author E-mail： phchengg@163.com E-mail:meganjing@126.com

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摘要： 目的 分析亚临床型生殖器疱疹 （GH） 患者的病毒脱排特点， 为临床治疗提供依据。方法 选取 2014 年 6 月—2016 年 6 月间我院收治的亚临床型 GH 患者 142 例， 荧光定量 PCR 法检测患者单纯疱疹病毒 （HSV） -DNA 脱排情况， 酶联免疫吸附试验（ELISA）检测患者血清 IgG 抗体类型。分析年龄、 性别、 抗体类型及病程长短、 发病频率对病毒脱排阳性率的影响。结果 142 例患者中 HSV-DNA 阳性率为 49.3%， 女性的病毒脱排阳性率高于男性 （P < 0.05）。血清 HSV-Ⅰ IgG++HSV-Ⅱ IgG+与单纯 HSV-Ⅱ IgG+患者病毒脱排阳性率差异无统计学意义， 但二者均高于单纯 HSV-Ⅰ IgG+患者。病程≤6 年的患者病毒脱排阳性率高于＞6 年者， 频发患者（复发≥6 次/年）高于少发患者（复发<6 次/年， 均 P < 0.05）。病程≤6 年的患者中， 频发患者高于少发患者， 而病程＞6 年的患者中， 频发与少发患者病毒脱排阳性率差异无统计学意义（P > 0.05）。同时女性患者 HSV-Ⅱ感染率高于男性（P < 0.05）。结论 亚临床型 GH 患者的病毒脱排阳性率与性别、 血清抗体类型、 病程及发病频率等因素密切相关。

关键词: 疱疹, 生殖器, 单纯疱疹病毒属, 疱疹病毒 1 型, 人, 疱疹病毒 2 型, 人, 病毒脱排, 抗体

Abstract: Objective To study the characteristics of shedding herpes simplex virus (HSV) in patients with subclinical genital herpes, and provide basis for clinical therapy. Methods A total of 142 patients with subclinical genital herpes were obtained in our hospital from June 2014 to June 2016. The fluorescent quantitation polymerase chain reaction was used to detect the HSV-DNA, and enzyme linked immunosorbent assay (ELISA) was applied to check the type of serum IgG. The effects of age, gender, antibody types, disease courses and occurrence frequency on the positive rate of HSV DNA shedding were analyzed. Results The positive rate of HSV-DNA in 142 patients was 49.3%, and females showed significantly higher HSV shedding rate than males (P < 0.05). There was no significant difference in HSV shedding rate between patients with serum HSV-Ⅰ IgG++HSV-Ⅱ IgG+ and patients with HSV-Ⅱ IgG+ alone, while both of which showed higher HSV shedding rate than those of patients with HSV- Ⅰ IgG + alone. Patients with short infection period (≤6 years) showed significantly higher HSV shedding rate than patients with longer infection period (>6 years). HSV shedding rate in patients with high frequent occurrence was found to be significantly higher than that in patients with low frequent occurrence (P < 0.05). In patients who showed short infection period (≤6 years), the HSV shedding rate was found significantly higher in frequent patients (recurrence ≥ 6 times/year) than that in few occurrence patients (recurrence < 6 times/year). There was no significant difference in HSV shedding rate in patients with recurrent occurrence when they went through more than 6 years’ HSV infection (P > 0.05). More patients with positive HSV- Ⅱ IgG were found in female than that in male (P < 0.05). Conclusion In patients with subclinical genital herpes, HSV shedding rate is closely related to gender, serum antibody type, disease course and recurrent occurrence.

Key words: herpes genitalis, simplexvirus, herpesvirus 1, human, herpesvirus 2, human, shedding of virus, antibodies