天津医药

天津医药 ›› 2017, Vol. 45 ›› Issue (3): 318-319.doi: 10.11958/20161167

• 临床研究 • 上一篇    下一篇

原发性肝癌 TACE 术后急性肿瘤溶解综合征一例

李阳， 张雅敏△， 侯建存   

  1. 天津市第一中心医院移植中心肝胆外科 （邮编 300192）
  • 收稿日期:2016-10-18 修回日期:2017-02-07 出版日期:2017-03-15 发布日期:2017-03-21
  • 通讯作者: 张雅敏 E-mail:zhangyamin@medmail.com.cn
  • 基金资助:
    天津市卫生局科技基金（2015KZ034）； 天津市应用基础与前沿技术研究计划（14JCYBJC24800）； 国家自然科学基金面上项目（81370576）

A case of acute tumor lysis syndrome after TACE operation for primary liver cancer

LI Yang, ZHANG Ya-min△, HOU Jian-cun   

  1. Department of Hepatobiliary Surgery, Transplant Center, Tianjin First Central Hospital, Tianjin 300192, China
  • Received:2016-10-18 Revised:2017-02-07 Published:2017-03-15 Online:2017-03-21
  • Contact: ZHANG Ya-min E-mail:zhangyamin@medmail.com.cn

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摘要： 摘要： 肿瘤溶解综合征（TLS）是肿瘤细胞快速溶解后细胞内容物及其代谢产物迅速释放入血， 引起一系列以高 尿酸、 高钾、 高磷、 低钙血症、 急性肾功能不全为特征的并发症； TLS 常见于对化疗敏感的恶性肿瘤， 少见于实体肿瘤。笔者发现 1 例原发性肝癌患者行肝动脉化疗栓塞术 （TACE） 后出现急性 TLS， 给予血液透析、 保肝及对症支持治疗后， 症状好转。

关键词: 肝肿瘤, 手术后并发症, 肿瘤溶解综合征, 肝动脉化疗栓塞术, 体外透析

Abstract: Abstract: Tumor lysis syndrome (TLS) is the rapid dissolution of tumor cells and cell contents, and its metabolite is rapidly released into the blood, causing a series of complications such as high uric acid, high potassium, high phosphorus,hypocalcemia and acute renal insufficiency. TLS is commonly seen in patients with rapidly growing malignant tumors that are sensitive to chemotherapy, and which is rare in solid tumors. We found one case of primary liver cancer with acute TLS, who was given hemodialysis to protect the liver and symptomatic treatment, and the patient is on the mend.

Key words: liver neoplasms, postoperative complications, tumor lysis syndrome, transcatheter arterial chemoembolization, extracorporeal dialysis