天津医药 ›› 2017, Vol. 45 ›› Issue (8): 799-803.doi: 10.11958/20170677

• 专题 颅脑神经创伤 • 上一篇    下一篇

颅脑创伤后凝血功能障碍的临床与循证

袁强, 胡锦△   

  1. 复旦大学附属华山医院神经外科 (邮编 200040)
  • 收稿日期:2017-06-09 修回日期:2017-07-07 出版日期:2017-08-15 发布日期:2017-08-15
  • 通讯作者: △通讯作者 E-mail: hujin_dana@126.com E-mail:hujin_dana@126.com
  • 作者简介:袁强 (1986), 男, 博士, 主治医师, 主要从事颅脑创伤与脑出血的基础与临床研究

Clinical and evidence-based study of coagulopathy after traumatic brain injury

YUAN Qiang, HU Jin△   

  1. Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2017-06-09 Revised:2017-07-07 Published:2017-08-15 Online:2017-08-15
  • Contact: △Corresponding Author E-mail: hujin_dana@126.com E-mail:hujin_dana@126.com

摘要: 颅脑创伤 (TBI) 后凝血功能障碍是指颅脑遭受创伤引起组织损伤后, 出现以凝血、 纤溶和抗凝途径激活为 主要临床表现的凝血功能紊乱, 是多因素、 多环节相互作用的结果, 其病理生理学机制复杂。本文综述了目前 TBI 后凝血功能障碍的临床特征与循证医学证据, 以总结 TBI 后凝血功能障碍诊治的最新进展。

关键词: 颅脑损伤, 循证医学, 凝血功能障碍, 进展性颅内出血

Abstract: Coagulopathy after traumatic brain injury is a coagulation dysfunction caused by brain tissue injury, which is characterized by over activations of coagulation, fibrinolysis and anticoagulation. It is the result of the interaction of multiple factors and multiple links with complicated pathophysiology. This study reivewed the clinical features and evidence-based evidences of coagulopathy after traumatic brain injury in order to summarize and discuss the latest progress in the diagnosis and treatment of coagulopathy after traumatic brain injury.

Key words: craniocerebral trauma, evidence based medicine, coagulopathy, progressive intracranial hemorrhage