天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (1): 109-112.doi: 10.11958/20170997

• 综述 • 上一篇    

脂肪来源间充质干细胞与免疫调节因子间 作用的研究进展

韩秋青 1，师帅南 2，王玉亮 2,3△   

  1. 1 天津市宁河区苗庄镇卫生院（邮编 301507）；2 天津医科大学第二医院检验科；3 天津市泌尿外科研究所
  • 收稿日期:2017-09-25 修回日期:2017-11-20 出版日期:2018-01-15 发布日期:2018-01-16
  • 通讯作者: 韩秋青 E-mail:hanqiuqing@163.com
  • 作者简介:韩秋青（1971），男，大专，副主任技师，主要从事临床检验研究
  • 基金资助:
    国家自然科学基金资助项目

Research progress on the relationship between ADSCs and immunomodulatory factors

HAN Qiu-qing1, SHI Shuai-nan2, WANG Yu-liang2,3△   

  1. 1 Health Center of Tianjin Ninghe District Miaozhuang Town, Tianjin 301507, China; 2 Department of Clinical Laboratory Medicine, the 2nd Hospital of Tianjin Medical University; 3 Tianjin Institute of Urology
  • Received:2017-09-25 Revised:2017-11-20 Published:2018-01-15 Online:2018-01-16

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摘要： 间充质干细胞（MSCs）是中胚层中具有高度自我更新和多向分化潜能的非造血多能干细胞，可以分化为成 脂细胞、成骨细胞、成软骨细胞、肝细胞、心肌细胞、神经元干细胞、胰岛样细胞等。MSCs 具有免疫调节特性，可通过 分泌吲哚胺-2,3-双加氧酶（IDO）和前列腺素 E2（PGE2）来发挥免疫调节作用，同时又能在炎性因子如干扰素 γ （IFN-γ）的预刺激下增强其免疫调节功能。研究发现，在脂肪组织中存在丰富的，使 MSCs 成为成年干细胞非常有吸 引力的来源。本文对目前脂肪来源间充质干细胞（ADSCs）和以上 3 种免疫调节因子之间相互作用的研究进展作一 综述。

关键词: 地诺前列酮, 神经免疫调节, 细胞因子类, 综述, 脂肪来源间充质干细胞, 吲哚胺-2,3-双加氧酶

Abstract: Mesenchymal stem cells (MSCs) are defined as undifferentiated cells that are capable of self renewal and functionally capable of differentiating into adipocytes, osteoblasts, chondrocytes, hepatocyte-like cells, myogenic-like cells, neuron-like cells, and islet-like cells. MSCs possess immunomodulatory properties according to secrete indoleamine-2,3- dioxygenase (IDO) and prostaglandin E2 (PGE2) to play the role of immunomodulatory. Moreover, pre-stimulation of interferon- γ (IFN- γ) can promote the immunomodulatory function of MSCs. High abundance of MSCs found in adipose tissue makes it a very attractive source of adult stem cells. This article reviews the recent progress in the interaction between adipose derived mesenchymal stem cells (ADSCs) and three immunomodulatory factors.

Key words: dinoprostone, neuroimmunomodulation, cytokines, review, adipose-derived mesenchymal stem cells, indoleamine-2,3-dioxygenas