天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (6): 654-656.doi: 10.11958/20171327

• 临床研究 • 上一篇    下一篇

抗-E及抗-Ec合并抗-Fyb致新生儿溶血症二例及文献复习

石武娟，穆郁，宋立，张芳，麻庆荣，王丹   

  1. 天津市儿童医院新生儿科（邮编300134）
  • 收稿日期:2017-11-23 修回日期:2018-03-12 出版日期:2018-06-15 发布日期:2018-07-05
  • 通讯作者: 石武娟 E-mail:13132163129@163.com

Case report and literature review of neonatal hemolysis induced by anti-E and anti-Ec combined with anti-Fyb

SHI Wu-juan, MU Yu, SONG Li, ZHANG Fang, MA Qing-rong, WANG Dan   

  1. Department of New Pediatric, Tianjin Children’s Hospital, Tianjin 300134, China
  • Received:2017-11-23 Revised:2018-03-12 Published:2018-06-15 Online:2018-07-05
  • Contact: wu-juan shi E-mail:13132163129@163.com

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摘要： 新生儿溶血病（HDN）在妊娠早期可引起流产、早产、胎儿水肿、胎儿宫内贫血甚至胎儿死亡；新生儿可出现黄疸、贫血、肝脾肿大、水肿、核黄疸后遗症等。本文回顾了抗-E及抗-Ec合并抗-Fyb致新生儿溶血症2例患者的诊疗经过，并复习了该病流行病学情况、诊断及治疗的相关文献资料，以提高对本病的认识。

关键词: 贫血, 溶血性, 免疫性, Rh-Hr血型系统, Duffy血型系统, 重症监护, 新生儿

Abstract: Hemolytic diseases of newborn (HDN) can cause miscarriage, premature birth, fetal edema, fetal intrauterine anemia and even fetal death in early pregnancy. Neonatus with HDN can have jaundice,anemia,hepatosplenomegaly, edema and nuclear jaundice sequelae. This article reviewed the diagnosis and treatment of two patients with HDN caused by anti -E and anti-Ec combined with anti-Fyb, and reviewed the relevant literature on the epidemilogy, the diagnosis and treatment of HDN in order to improve the understanding of the disease.

Key words: anemia, hemolytic, isoimmune, Rh-Hr blood-group system, Duffy blood-group system, intensive care, neonatal