天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (7): 776-789.doi: 10.11958/20180055

• 综述 • 上一篇    下一篇

线粒体ATP敏感性钾通道在糖尿病合并脑缺血损伤中 作用的研究进展

施宁华，韩江全△，邓才洪，何婧   

  1. 广东省珠海市遵义医学院第五附属（珠海）医院神经内科（邮编519100）
  • 收稿日期:2018-01-10 修回日期:2018-03-22 出版日期:2018-07-15 发布日期:2018-07-15
  • 通讯作者: 施宁华 E-mail:1252704187@qq.com
  • 作者简介:施宁华（1992），女，硕士在读，主要从事脑血管病研究
  • 基金资助:
    珠海市重点学科项目

The research progress of mitoKATP in diabetes with cerebral ischemic injury

SHI Ning-hua, HAN Jiang-quan△, DENG Cai-hong, HE jing   

  1. Department of Neurology, the Fifth Affiliated (Zhuhai) Hospital, Zunyi Medical College, Zhuhai 519100，China △Corresponding Author E-mail:gdshanjq@163.com
  • Received:2018-01-10 Revised:2018-03-22 Published:2018-07-15 Online:2018-07-15

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摘要： 糖尿病是脑血管疾病重要的独立危险因素，大量的临床和实验研究证实，糖尿病可加重脑缺血损伤，但其 机制尚不十分清楚。线粒体ATP敏感性钾通道（mitoKATP）是位于线粒体内膜上一种重要的离子通道，在许多生理病 理过程中发挥重要功能。近年来，不断有研究表明，mitoKATP对脑缺血损伤有保护作用，而糖尿病可使其启动的正常 保护机制受损，mitoKATP与糖尿病合并脑缺血损伤的关系受到大家越来越多的关注。本文就mitoKATP在糖尿病合并脑 缺血损伤中的作用作一综述。

关键词: 糖尿病, 脑缺血, KATP通道, 线粒体, 综述

Abstract: Diabetes is an important independent risk factor for cerebrovascular diseases. A large number of clinical and experimental studies have confirmed that diabetes can aggravate cerebral ischemic injury, but the mechanism is not yet clear. Mitochondrial ATP-sensitive potassium channel (mitoKATP) is an important ion channel located in the mitochondrial inner membrane, playing very important roles in many physiological and pathological processes. In recent years, studies have showed that mitoKATP has a protective effect on cerebral ischemic neuronal injury, but its protective mechanism is abolished in diabetes. The relationship between mitoKATP and diabetes with cerebral ischemic injury has attracted more and more attention. In this article, the role of brain mitoKATP in diabetes with cerebral ischemic injury was reviewed.

Key words: diabetes mellitus, brain ischemia, KATP channels, mitochondria, review