天津医药 ›› 2018, Vol. 46 ›› Issue (7): 770-775.doi: 10.11958/20180272

• 综述 • 上一篇    下一篇

干燥综合征腺体外损害的治疗进展

李奔,薛鸾△   

  1. 上海中医药大学附属岳阳中西医结合医院风湿科(邮编200437)
  • 收稿日期:2018-02-23 修回日期:2018-03-07 出版日期:2018-07-15 发布日期:2018-07-15
  • 通讯作者: 薛鸾 E-mail:xelco@163.com
  • 作者简介:李奔(1985),女,硕士研究生,主治医师,主要从事免疫细胞参与干燥综合征慢性炎症反应机制的研究
  • 基金资助:
    桑珠滋阴口服液治疗原发性干燥综合征的院内制剂再注册评价研究;清热解毒法通过pDC-I型IFN-CXCL13轴治疗干燥综合征的机制研究

Advances in the treatment of extraglandular damage of Sjogren’s syndrome

LI Ben, XUE Luan△   

  1. Department of Rheumatology and Immunology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China △Corresponding Author E-mail: xelco@163.com
  • Received:2018-02-23 Revised:2018-03-07 Published:2018-07-15 Online:2018-07-15

摘要: 原发性干燥综合征(pSS)是以累及外分泌腺为主的慢性系统性自身免疫病,除累及涎腺和泪腺导致口干 眼干外,还可累及腺体外器官而出现多系统损害。目前国内外对干燥综合征尚无一种肯定有效的全身治疗药物。 针对腺体外损害多是借鉴类风湿关节炎、系统性红斑狼疮等的治疗经验或根据临床经验应用糖皮质激素和免疫抑 制剂等。生物制剂在干燥综合征治疗方面虽前景广阔,但仍存在争议。本文将重点对干燥综合征腺体外损害的治 疗进展进行综述,希望对干燥综合征的临床治疗有所帮助。

关键词: 干燥综合征, 自身免疫病, 腺体外, 综述

Abstract: Primary Sjogren’s syndrome (pSS) is a chronic systemic autoimmune disease mainly involving exocrine glands. Besides the involvement of salivary glands and lacrimal glands, it can also involve multiple external organs of glands, resulting in multiple system damage. At present, there is no effective systemic treatment for Sjogren’s syndrome at home and abroad. Most of the treatment for lesions outside glands are learned from the treatment for rheumatoid arthritis, systemic lupus erythematosus, or glucocorticoids or immunosuppressants based on clinical experience. Although biological agents have broad prospects in the treatment of Sjogren’s syndrome, there are still many disputes. This article will focus on the progress of the treatment for Sjogren’s syndrome of external organs of glands, and hope that it can be helpful to the clinical treatment of Sjogren syndrome.

Key words: Sjogren’s syndrome, autoimmune disease, external organs of the gland, review