天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (10): 1123-1126.doi: 10.11958/20180738

• 综述 • 上一篇    下一篇

CD4+T细胞的分化调节及其在再生障碍性贫血中 作用的研究进展

张珊，宋新龙，王爱迪，谢东杰，张乐，刘宝山△   

  1. 基金项目：国家自然科学基金重点项目（81774062，81173415）；天津医科大学“十三五”综合投资学科建设项目（11601501-2017xk0301） 作者单位：天津医科大学总医院中医科（邮编300052） 作者简介：张珊（1993），女，硕士研究生在读，主要从事中西医治疗血液病相关研究 △通讯作者 E-mail:j33387@qq.com
  • 收稿日期:2018-05-08 修回日期:2018-07-03 出版日期:2018-10-15 发布日期:2018-11-09
  • 通讯作者: 刘宝山 E-mail:j33387@qq.com
  • 基金资助:
    穿龙薯蓣皂苷调控HIF-1/Notch网络串联信号干预再障骨髓T细胞分化的机制研究;经典Wnt信号通路在再生障碍性贫血发病中的作用及穿龙薯蓣皂苷的干预机制

The research development of CD4+ T cells and their molecular regulatory mechanism in aplastic anemia

ZHANG Shan, SONG Xin-long, WANG Ai-di, XIE Dong-jie, ZHANG Le, LIU Bao-shan△   

  1. Department of Traditional Chinese Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China △Corresponding Author E-mail: j33387@qq.com
  • Received:2018-05-08 Revised:2018-07-03 Published:2018-10-15 Online:2018-11-09

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摘要： 摘要：CD4+ T细胞接受抗原的刺激后能够分化为多种辅助性T细胞（Th细胞）和调节性T细胞（Treg），是人体免 疫系统重要的组成部分。随着对再生障碍性贫血和CD4+ T细胞研究的不断深入，发现CD4+ T细胞各亚群平衡失衡、 功能亢进及细胞因子的异常活化造成的骨髓损伤是诱导再生障碍性贫血发病的重要原因。因此，研究CD4+ T细胞 各个亚群的细胞分化调节，分析CD4+ T细胞在再生障碍性贫血中的作用机制，可为再生障碍性贫血患者细胞亚群平 衡的恢复提供治疗思路。本文拟从CD4+ T细胞、相关细胞因子等方面阐述CD4+ T细胞免疫异常对再障机制及治疗 的影响。

关键词: 贫血, 再生障碍性, 综述, CD4+ T细胞, Th1, Th2, Treg, Th17

Abstract: Abstract: CD4+ T cells can differentiate into a variety of auxiliary T cells (Th cells) and regulatory T cells (Treg) after the stimulation of antigen, which is an important part of human immune system. With the further study of aplastic anemia and CD4+ T cells, it is found that the imbalance of CD4+ T cell subsets, hyperfunction and bone marrow injury caused by abnormal activation of cytokines are important causes of the pathogenesis of aplastic anemia. Therefore, the study of cell differentiation and regulation of CD4+ T cells and the analysis of the mechanism of CD4+ T cells in aplastic anemia can provide therapeutic ideas for the recovery of cell subpopulation balance in patients with aplastic anemia. In this paper, the effects of CD4+ T cell immune abnormalities on the mechanism and treatment of aplastic anemia were discussed from the aspects of CD4+ T cells and related cytokines.

Key words: anemia, aplastic, review, CD4+ T cells, Th1, Th2, Treg, Th17