天津医药 ›› 2019, Vol. 47 ›› Issue (10): 1102-1107.doi: 10.11958/20191036

• 综述 • 上一篇    下一篇

肠道细菌与肥胖及2型糖尿病关系的研究进展

袁冰舒,赵海龙,李丽娟△   

  1. 贵州省遵义市,遵义医科大学病理生理学教研室(邮编563000)
  • 收稿日期:2019-04-02 修回日期:2019-06-01 出版日期:2019-10-15 发布日期:2019-11-11
  • 通讯作者: 袁冰舒 E-mail:381411689@qq.com
  • 基金资助:
    国家自然科学基金;贵州省科学技术基金

Research progress on relationship between intestinal flora and obesity and type 2 diabetes

YUAN Bing-shu, ZHAO Hai-long, LI Li-juan△   

  1. Department of Pathophysiology, Zunyi Medical University, Zunyi 563000, China
  • Received:2019-04-02 Revised:2019-06-01 Published:2019-10-15 Online:2019-11-11
  • Contact: YUAN Bing-shu E-mail:381411689@qq.com
  • Supported by:
     

摘要: 摘要:肠道菌群是定植在肠道的微生物群,其微生态平衡受生活环境、生活方式、饮食习惯及药物等多种因素影 响而发生改变,这些改变是多种疾病发生的病理基础。越来越多的证据显示,肠道菌群中的硬壁菌门、变形菌门、放 线菌门及拟杆菌门等,可通过免疫、代谢及生物钟途径参与肥胖及2型糖尿病(T2DM)的发生发展,目前肠道菌群与 肥胖及T2DM的关系已成为研究热点。本文就两者的相关研究进展进行综述,望有助于进一步阐明肥胖及T2DM的 发病机制,并为寻找两者的治疗靶点提供一些新的思路。

关键词: 肠杆菌科, 肥胖症, 糖尿病, 2型, 糖代谢紊乱, 脂代谢紊乱

Abstract: Abstract: Intestinal flora is the microflora colonized in the intestine. Intestinal flora microecological balance can be affected by various factors, including living environment, life style, eating habits and drugs. These changes are the pathological basis of many diseases. Increasing evidence shows that intestinal flora including Firmicutes, Proteobacteria, Actinobacteria and Bacteroidetes, can increase the incidence of obesity and type 2 diabetes (T2DM) through immune, metabolic and circadian clock pathways. These researches have become the focus of academic discussion. This article summarizes the relationship between changes in intestinal flora and obesity and T2DM in recent years, in order to further clarify the pathogenesis of obesity and T2DM, and provide some new ideas for finding therapeutic targets.

Key words: enterobacteriaceae, obesity, diabetes mellitus, type 2, glucose metabolism disorders, lipid metabolism disorders

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