天津医药 ›› 2020, Vol. 48 ›› Issue (3): 216-219.doi: 10.11958/20192908

• 临床研究 • 上一篇    下一篇

眼内转移性肿瘤的诊疗分析

任明玉,吴一湘,韩瑞娟,周美美,李瑞淼,刘立民   

  1. 河北省邢台市,河北省眼科医院眼眶病与眼肿瘤科(邮编054001)
  • 收稿日期:2019-09-23 修回日期:2019-12-07 出版日期:2020-03-15 发布日期:2020-04-11
  • 通讯作者: 任明玉 E-mail:147237583@qq.com

Clinical features and treatment of intraocular metastatic tumors

REN Ming-yu,WU Yi-xiang,HAN Rui-juan,ZHOU Mei-mei,LI Rui-miao,LIU Li-min   

  1. Department of Orbital Disease and Ocular Tumor, Hebei Eye Hospital, Xingtai 054001, China
  • Received:2019-09-23 Revised:2019-12-07 Published:2020-03-15 Online:2020-04-11
  • Contact: Ming-yu REN E-mail:147237583@qq.com

摘要: 目的 分析眼内转移性肿瘤的临床特征、治疗以及预后特点。方法 通过对 16例患者进行回顾性分析,对眼内转移性肿瘤的临床表现、影像学等检查以及其治疗和预后等方面情况进行研究。结果 本组病例均以眼部症状为首发症状;眼底检查显示10例为灰黄色,3例为暗红色,3例存在明显视网膜脱离、渗出,掩盖肿物存在;其中5例出现新生血管青光眼;16例B超显示均为实性,其中11例伴有局限性视网膜脱离;超声多普勒显示6例血流丰富,9例可见少量点状血流信号,1例未发现明确血流信号;眼眶 CT显示 10例有明确肿物存在,6例仅可见局部球壁增厚;其中11例行眼眶MRI检查,T1WI与T2WI均中等信号影。随访3个月~2年,患者均发现全身病灶,肺癌6例,消化系统肿瘤6例,乳腺癌3例,子宫内膜癌1例;9例因全身病变已死亡,7例随访在6个月以内,全身状况较差,其中3例已出现明显恶病质。结论 眼内转移性肿瘤为实性病变,完善的眼部检查,结合详细的病史以及全身检查十分必要,但不应只是关注眼内病变,而导致全身病灶的遗漏。

关键词: 眼肿瘤, 肿瘤转移, 脉络膜肿瘤

Abstract: Objective To analyze the clinical features, treatment and prognosis of intraocular metastatic tumors.Methods Sixteen patients were retrospectively analyzed to study the clinical manifestations, imaging features,treatment and prognosis of intraocular metastatic tumors. Results The ocular symptom was the first symptom in all cases. Fundus examination showed that 10 cases were grayish yellow, 3 cases were dark red, and 3 cases showed obvious retinal detachment and exudation, which covered the presence of masses. Neovascular glaucoma was found in 5 cases. Ultrasound showed that all the cases were solid lesions, and 11 cases with local retinal detachment. Ultrasound color doppler showed abundant blood flow in 6 cases, small point blood flow signal in 9 cases, and no clear blood flow signal in 1 case. Orbital CT showed definite mass in 10 cases, and local ball wall thickening in 6 cases. Eleven cases underwent orbital MRI examination, T1WI and T2WI showed moderate signal of lesion. After 3 months to 2 years of follow-up, patients were found systemic lesions,including 6 cases of lung cancer, 6 cases of digestive system tumors, 3 cases of breast cancer, and 1 case of endometrial cancer. Nine cases died of systemic disease, and 7 cases followed-up within 6 months. The general condition of the 7 cases was poor, and 3 cases showed obvious cachexia. Conclusion Intraocular metastatic tumors are solid lesions. Comprehensive ocular examination, combined with detailed medical history, and systemic examinations should be performed to detect systemic lesions in time to prevent the omission of systemic lesions.

Key words: eye neoplasms, neoplasm metastasis, choroid neoplasms