关键词: 子宫内膜增生, 子宫内膜肿瘤, 癌, 危险因素, 异常子宫出血, 年轻女性, 出血模式, 三线征

Abstract: Objective　To analyze the risk factors and clinical characteristics of endometrial hyperplasia or carcinoma in young women, and to provide a reference method for clinical diagnosis and treatment. Methods　A retrospective analysis was performed on 243 cases who underwent hysteroscopy and curettage for abnormal uterine bleeding, infertility or ultrasonic abnormalities from January 2017 to January 2019 in the Tianjin Medical University General Hospital. The patients with endometrial hyperplasia or carcinoma were the case group (105 cases), and the patients with normal endometrium were the control group (138 cases). Clinical data of two groups of patients were collected. And ultrasound imaging data were compared to analyze the risk factors and ultrasound imaging features of endometrial hyperplasia or carcinoma. Results　Multivariate Logistic regression analysis showed that combined diabetes, abnormal uterine bleeding, abnormal uterine bleeding time ≥ 6 months, and obesity were independent risk factors affecting endometrial hyperplasia or carcinoma (P＜0.05). The proportion of patients with thin menstruation and irregular uterine bleeding, endometrial thickening, endometrium hyperechoic and no third-line sign was significantly higher in the case group than that of control group (P＜0.01). Conclusion　This study suggests that young women with obesity, diabetes, abnormal uterine bleeding, and abnormal uterine bleeding time ≥ 6 months are more likely to develop endometrial hyperplasia or carcinoma and have certain characteristic clinical manifestations. In clinical treatment, we should pay attention to the control of related risk factors.

Key words: endometrial hyperplasia, endometrial neoplasms, carcinoma, risk factors, abnormal uterine bleeding, young women, bleeding pattern, trilaminar pattern