基于卵母细胞质量下降的卵泡液多组学研究进展

doi:10.11958/20253362

天津医药 ›› 2026, Vol. 54 ›› Issue (4): 444-448.doi: 10.11958/20253362

• 综述 • 上一篇

基于卵母细胞质量下降的卵泡液多组学研究进展

蔡余文¹(), 申亚辉², 满淑丽¹, 叶盛英², 马艳华²^△()

¹ 天津科技大学生物工程学院（邮编300457）
² 中国人民解放军联勤保障部队第九八三医院生殖医学科

收稿日期:2025-11-24 修回日期:2025-12-18 出版日期:2026-04-15 发布日期:2026-04-14
通讯作者: ^△E-mail：mayanhuahh@sina.com
作者简介:蔡余文（2002），女，硕士在读，主要从事生物医药与辅助生殖方面研究。E-mail：caiyuwen0915@163.com
基金资助:
联勤医学优质学科建设课题(145AHQ146609000X)

Advances in multi-omics research of follicular fluid based on the decline in oocyte quality

CAI Yuwen¹(), SHEN Yahui², MAN Shuli¹, YE Shengying², MA Yanhua²^△()

¹ School of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
² Department of Reproductive Medicine, the 983rd Hospital of the Joint Logistics Support Force, People's Liberation Army

Received:2025-11-24 Revised:2025-12-18 Published:2026-04-15 Online:2026-04-14
Contact: ^△E-mail: mayanhuahh@sina.com

蔡余文, 申亚辉, 满淑丽, 叶盛英, 马艳华. 基于卵母细胞质量下降的卵泡液多组学研究进展[J]. 天津医药, 2026, 54(4): 444-448.

CAI Yuwen, SHEN Yahui, MAN Shuli, YE Shengying, MA Yanhua. Advances in multi-omics research of follicular fluid based on the decline in oocyte quality[J]. Tianjin Medical Journal, 2026, 54(4): 444-448.

摘要/Abstract

摘要：

随着多组学技术的快速发展，卵泡液的代谢组学、蛋白质组学和转录组学研究不断深入，为解析卵母细胞质量下降的分子机制提供了新的视角。卵巢功能减退及生殖衰老过程中，卵泡液中激素水平、能量代谢和脂质代谢特征发生显著改变，并伴随炎症与免疫相关通路失衡。卵泡液中的多种关键蛋白，不仅参与排卵、组织重塑及信号转导，还与卵母细胞质量和胚胎发育结局密切相关。该文系统总结卵泡液的多组学研究进展，并探讨其在卵母细胞质量评估及精准辅助生殖技术决策中的潜在应用价值。

关键词: 卵泡液, 卵母细胞, 代谢组学, 蛋白质组学, 转录组, 生殖技术, 辅助

Abstract:

In recent years, rapid advances in multi-omics technologies have substantially promoted metabolomic, proteomic and transcriptomic investigations of follicular fluid (FF), providing novel insights into the molecular mechanism underlying oocyte quality deterioration. During the process of ovarian function decline and reproductive aging, hormone levels, energy metabolism and lipid metabolism characteristics in FF have undergone significant changes. It is accompanied by the imbalance in inflammatory and immune-related pathways. A variety of key proteins in FF not only participate in ovulation, tissue remodeling and signal transduction, but are also closely related to the quality of oocytes and the outcome of embryonic development. This review systematically summarizes recent progress in FF-based multi-omics research and discusses its potential applications in oocyte quality assessment and precision decision-making in assisted reproductive technologies.

Key words: follicular fluid, oocytes, metabolomics, proteomics, transcriptome, reproductive techniques, assisted

中图分类号:

R711.75

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基于卵母细胞质量下降的卵泡液多组学研究进展

Advances in multi-omics research of follicular fluid based on the decline in oocyte quality

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