天津医药 ›› 2015, Vol. 43 ›› Issue (3): 288-291.doi: 10.11958/j.issn.0253-9896.2015.03.018

• 专题研究·心血管疾病 • 上一篇    下一篇

心率减速力对急性心肌梗死后猝死风险的预测价值

李杨, 秦勤, 寇璐, 陈刚, 路雅茹   

  1. 天津市胸科医院心内科 (邮编 300222

  • 收稿日期:2014-10-11 修回日期:2014-11-17 出版日期:2015-03-15 发布日期:2015-03-15
  • 通讯作者: 秦勤 E-mail:liyang8014@163.com
  • 作者简介:李杨 (1980), 女, 主治医师, 博士, 主要从事冠心病的基础与临床研究
  • 基金资助:
    天津市科技支撑计划项目 (10ZCKFSF00800

The predictive value of deceleration capacity of heart rate for sudden cardiac death after acute myocardial infarction

LI Yang, QIN Qin, KOU Lu, CHEN Gang, LU Yaru#br# #br#   

  1. Department of CardiologyTianjin Chest HospitalTianjin 300222China
  • Received:2014-10-11 Revised:2014-11-17 Published:2015-03-15 Online:2015-03-15
  • Contact: QIN Qin E-mail:liyang8014@163.com

摘要: 目的 探讨急性 ST 段抬高型心肌梗死后早期无创性指标心率减速力 (DC) 对急性心肌梗死患者发生心脏性猝死 (SCD) 的预测价值。方法 以 417 例急性 ST 段抬高型心肌梗死患者为研究对象, 入院后行 24 h 动态心电图检查, 计算 DC 值, 临床随访观察 12 个月, 记录发生的 SCD 事件 (SCD 组), 并与未发生 SCD 者 (存活组) 比较各观测指标。结果 在心肌梗死后 12 个月内, 20 例 (4.8%) 患者发生 SCD。与存活组患者相比, SCD 组患者的左室射血分数 (LVEF) 和 DC 值明显降低 [0.393±0.065 vs 0.528±0.042,(2.85±1.66) ms vs(5.49±1.71) ms, 均 P<0.05]。多因素 Cox 回归分析显示, LVEF <0.35[RR(95%CI): 2.167(1.384~4.661), P=0.013]和 DC<4.5 ms[RR(95%CI): 3.706(2.709~ 5.374), P=0.020] 为发生 SCD 的危险因素。LVEF 和 DC 降低预测 SCD 发生的敏感度分别为 52.1%和 76.4%, 特异度分别为 84.5%和 86.1%。结论 急性心肌梗死后 DC 值的降低能预测远期 SCD 的发生。

关键词: 心肌梗死, 猝死, 心脏, 左室射血分数, 心率减速力

Abstract: Objective To investigate the predictive value of the non-invasive indicator deceleration capacity of heart rate (DC) in the sudden cardiac death (SCD) after acute myocardial infarction. Methods A total of 417 myocardial infarc⁃ tion patients with ST-segment elevation in sinus rhythm were enrolled in this study. DC was assessed from data of 24-hour ECG Holter. Regular follow-ups were carried out within 12 months. The SCD events were recorded and compared with patients without SCD. Results During 12 months of follow-up, 20 patients were died due to SCD (4.8%). Compared with sur⁃ vival group, patients showed significantly lower left ventricular ejection fraction (LVEF, 0.393 ± 0.065 vs 0.528 ± 0.042, P<0.05) and DC [(2.85±1.66) ms vs (5.49±1.71) ms, P<0.05]in SCD group. Multivariate Cox proportional hazard regression analysis showed that lower LVEF(<0.35)[RR: 2.167(1.384- 4.661), P=0.013]and DC (DC<4.5 ms)[RR: 3.706(2.709- 5.374), P=0.020] were risk factors for the occurrence of SCD. The prediction sensitivity by the decreased LVEF and DC was 52.1% and 76.4% respectively, and the specificity was 84.5% and 86.1% respectively. Conclusion The decreased value of DC after acute myocardial infarction can predict the SCD events.

Key words: myocardial infarction, death, sudden, cardiac, left ventricular ejection fraction, deceleration capacity of rate