天津医药 ›› 2015, Vol. 43 ›› Issue (8): 939-942.doi: 10.11958/j.issn.0253-9896.2015.08.030

• 综述 • 上一篇    下一篇

表皮生长因子受体运输与肿瘤治疗的研究进展

陈路,谭超   

  1. 湖北宜昌,三峡大学第一临床医学院
  • 收稿日期:2014-11-24 修回日期:2015-03-09 出版日期:2015-08-15 发布日期:2015-08-15
  • 通讯作者: 谭超 E-mail:yczxyytanchao@sina.com
  • 作者简介:陈路(1972),男,主治医师,学士,主要从事病理、肿瘤研究
  • 基金资助:
    湖北省自然科学基金资助项目(2014CFB307)

Correlation study of endothelial growth factor receptor transportation with tumor treatment

CHEN Lu, TAN Chao   

  1. The First Clinical Medical College, China Three Gorges University, Yichang 443002, China
  • Received:2014-11-24 Revised:2015-03-09 Published:2015-08-15 Online:2015-08-15

摘要: 表皮生长因子受体(EGFR)信号传导异常参与了肿瘤的发生发展,已经作为抗肿瘤治疗的靶点。本文在 EGFR 信号传导失调相关机制的基础上,对EGFR 信号传导过程中产生的运输异常及其癌基因的相互作用、EGFR 靶向药物在肿瘤治疗中的应用作一综述,以期为以EGFR 为靶点的肿瘤治疗方法以及其参与肿瘤耐药相关的最新研究提供参考。

关键词: 受体, 表皮生长因子, 信号传导, 癌基因, 肿瘤治疗方案, 综述

Abstract: Abnormal endothelial growth factor receptor transportion was involved in the development of tumor so more and more researches focus it as a target of anti-tumor therapy. Based on the known mechanism in EGFR mis-localization this review summarized the latest research progress in the abnormality in signal of EGFR transportation and its role in tumori⁃ genesis, anti-tumor drug and therapy that target to EGFR. It is aim to provide reference for the development of anti-tumor treatments which target EGFR and for the mechanism in resistance of anti-tumor.

Key words: receptor, epidermal growth factor, signal transduction, oncogenes, antineoplastic protocols, review