天津医药 ›› 2015, Vol. 43 ›› Issue (12): 1467-1469.doi: 10.11958/j.issn.0253-9896.2015.12.033

• 综述 • 上一篇    下一篇

Sox2 在胶质母细胞瘤中的研究进展

郭金满,谭超△,胡火军,谭园   

  1. 湖北宜昌,三峡大学第一临床医学院(邮编443002)
  • 收稿日期:2015-03-19 修回日期:2015-07-21 出版日期:2015-12-15 发布日期:2015-12-11
  • 通讯作者: △审校者和通讯作者E-mail: yczxyytanchao@sina.com E-mail:yczxyytanchao@sina.com
  • 作者简介:郭金满(1975),男,副主任医师,学士,主要从事神经外科、肿瘤等研究
  • 基金资助:
    湖北省自然科学基金资助项目(2014CFB307)

Current research of the role of Sox2 in Glioblastoma Multiforme

GUO Jinman,TAN Chao△,HU Huojun,TAN Yuan   

  1. The First Clinical Medical College, China Three Gorges University, Yichang 443002, China
  • Received:2015-03-19 Revised:2015-07-21 Published:2015-12-15 Online:2015-12-11
  • Contact: △Reviser and Corresponding Author E-mail: yczxyytanchao@sina.com E-mail:yczxyytanchao@sina.com

摘要: 胶质母细胞瘤(GBM)属于世界卫生组织(WHO)Ⅳ级恶性肿瘤,是除脑干胶质瘤外预后较差的中枢神经系统癌症,发病率占人原发性恶性脑肿瘤的80%,患者5 年生存率仅有5%。Sox2 是一种多能性调节子,越来越多的证据表明,Sox2 的突变及其功能异常与GBM 的发生密切相关。已有研究证实利用Sox2 基因作为GBM 治疗靶点具可行性。本文在此将Sox2 在GBM 中的新研究进展进行综述。

关键词: 胶质母细胞瘤, 中枢神经系统肿瘤, 基因疗法, 综述, Sox2

Abstract: Glioblastoma (GBM) is one of the WHO grade Ⅳmalignancies, which is an acentral nervous system cancer with poor prognosis unless the lesion is in the brain stem. The incidence of GBM accounts for 80% of human primary malignant tumors in brain. Only 5% GBM can survive up to 5-years. Many researches showed that Sox2 is a pluripotent regulator, and muta⁃ tion or abnormal function of Sox2 are closely related to the development of GBM. There are studies demonstrated the possibil⁃ ity of using Sox2 gene as apotential target for GBM therapy. This paper reviewed recent progress in GBM.

Key words: glioblastoma, central nervous system neoplasms, gene therapy, review, Sox2