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血尿酸水平与2型糖尿病患者血管并发症的关系

徐蓉   

  1. 天津医学高等专科学校
  • 收稿日期:2011-04-14 修回日期:2011-07-05 出版日期:2011-11-15 发布日期:2011-11-15
  • 通讯作者: 徐蓉

The Relationship between Serum Uric Acid and the Vascular Complications in Patients with Type 2 Diabetes Mellitus

Rong XU   

  • Received:2011-04-14 Revised:2011-07-05 Published:2011-11-15 Online:2011-11-15
  • Contact: Rong XU

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摘要： 摘要 目的：探讨血尿酸（SUA）水平与2型糖尿病（T2DM）患者血管并发症的关系及可能的作用机制。方法：收集1 040例T2DM患者，根据患者血尿酸水平分为高尿酸血症（HUA，男性SUA≥420 μmol/L,绝经前≥360 μmol/L）组117例和正常血尿酸（NUA）组923例，比较2组间主要临床指标以及血管并发症发生情况的差异。结果：（1）HUA组糖尿病肾病（DN）、高血压、脑血管病变发病率均为高于NUA组，差异有统计学意义（P＜0.01）。（2）HUA与NUA组间体质量指数（BMI）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、糖化血红蛋白（HbA1c）的差异有统计学意义（P＜0.05）。（3）多因素非条件Logistic回归分析示BMI、TG、HDL、HbA1c为血尿酸水平的影响因素。结论：T2DM合并高尿酸血症患者血管并发症的发生率更高，应重视血尿酸这一危险因素。

关键词: 尿酸, 糖尿病、2型, 血管并发症

Abstract: Abstract Objective: To investigate the relationship between serum uric acid (SUA) and vascular complications in patients of type 2 diabetes mellitus (T2DM), and the possible mechanism thereof. Methods: The collected clinical data of 1040 patients with T2DM were retrospectively reviewed. According to SUA levels, 1040 patients of T2DM were divided into hyperuricemia (HUA) group (SUA≥420 μmol/L, n=117) and normal uric acid (NUA) group (n=923). The differences in clinical indicators and the incidence of vascular complications were compared between patients of two groups. Results: (1) The incidence rates of diabetic nephropathy (DN), hypertension and cerebrovascular complications were significantly higher in patients of HUA group than those of NUA group (P<0.01). (2) There were significant differences in body mass index (BMI), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and hemoglobin A1C (HbA1c) between HUA group and NUA group (P<0.05). (3)The multivariable non-conditional Logistic analysis showed that the values of BMI, TG, HDL-C and HbA1c were influencing factors of SUA. Conclusion: The incidence of vascular complications was higher in T2DM patients with hyperuricemia. Therefore, much attention should be paid to the risk factor of SUA.