天津医药

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rhGH替代治疗对生长激素缺乏症患儿线性生长及空腹血糖的影响

王颖1,郑荣秀1,刘戈力2,杨箐岩1,崔敬茹3,姜丽红4   

  1. 1. 天津医科大学总医院
    2. 天津医科大学总医院儿科
    3. 天津医科大学
    4. 天津医大总医院儿科
  • 收稿日期:2011-06-15 修回日期:2011-07-12 出版日期:2012-02-15 发布日期:2012-02-15
  • 通讯作者: 王颖

Effects of Recombinant Human Growth Hormone Replacement Therapy on Linear Growth and Fasting Blood Glucose in Children with Growth Hormone Deficiency

  • Received:2011-06-15 Revised:2011-07-12 Published:2012-02-15 Online:2012-02-15

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摘要： 摘要 目的：观察国产重组人生长激素(rhGH)替代治疗对生长激素缺乏症(GHD)患儿的治疗效果及短期替代治疗对空腹血糖（FBG）的影响。方法：用国产rhGH治疗确诊为GHD的患儿25例，剂量为0.1~0.15 U/（kg?d），每晚睡前皮下注射，每周6~7次。分别于治疗前及治疗3、6个月后进行随诊，由专人用同一量具测量患儿身高（Ht），体质量(Wt),计算体质指数（BMI）、身高标准差积分（HtSDS）,禁食8 h以上取上午8时空腹静脉血检测FBG。结果：rhGH治疗3、6个月后患儿HtSDS由-2.30±0.44分别增加至-1.77±1.23、-1.74±0.58（P<0.05或P<0.01），生长速率较治疗前明显提高（P<0.01），FBG较治疗前增高（P<0.05），但FBG尚均在正常范围。治疗3、6个月后的FBG均与初始治疗年龄呈正相关(r分别为0.418、0.456，P<0.05)。结论：国产rhGH短期替代治疗可以提高GHD患儿身高，治疗对空腹血糖有影响，初始治疗年龄较大者更应在治疗期间动态监测血糖。

关键词: 侏儒症, 垂体性, 人生长激素, 血糖, 身高, 儿童

Abstract: Abstract Objective：To explore the therapeutic effects of replacement therapy with domestic recombinant human growth hormone(rhGH) on the liner growth and the fasting blood-glucose in children with growth hormone deficiency(GHD) . Methods: 25 GHD children were treated with rhGH and the dose is 0.1-0.15U/（kg.d）.They use it 6-7times every week by subcutaneous injection .Height (Ht) and weight (Wt) were measured by designate personnel using the same measuring tool before and after treatment for 3 and 6months .Body mass index (BMI) and Height standard deviation score (HtSDS) were computed. Fasting blood-glucose test were performed to test fasting blood-glucose (FBG) during 8 am. And children had no food or drink at least 8 hours before the test. Results：After 3 and 6 months of rhGH therapy, the HtSDS increased from -2.30±0.44 to-1.77±1.23(P<0.05), -1.74±0.58 (P<0.001) and the HV increased observably (P<0.001). FBG increased after the 3 and 6 months treatment (P<0.05), but still in a normal range and the FBG was age-related (r=0.418、0.456，P<0.05). Conclusion：The replacement of the rhGH can improve the height of children with GHD and affect the fasting glucose in children with GHD. We should dynamically monitor the fasting glucose during the treatment especially for the children with bigger initial treatment age.