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Livin和Smac在膀胱移行细胞癌中的表达及相关性研究

李清林1,蒋雷鸣2,伍运筹2   

  1. 1. 南京军区福州总医院进修实习楼2018室
    2. 广西桂林医学院附属医院
  • 收稿日期:2011-05-16 修回日期:2011-10-06 出版日期:2012-02-15 发布日期:2012-02-15
  • 通讯作者: 李清林

Expression of Livin and Smac and Their Relationship in Bladder Transitional Cell Carcinoma

  • Received:2011-05-16 Revised:2011-10-06 Published:2012-02-15 Online:2012-02-15
  • Contact: LI Qing Lin

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摘要： 摘要 目的：探讨Livin蛋白和Smac蛋白在膀胱移行细胞癌（BTCC）中的表达及两者的相关性。方法：应用免疫组化SABC法检测42例BTCC组织和18例癌旁正常黏膜组织中Livin蛋白和Smac蛋白的表达情况，并分析两者与BTCC临床病理特征的关系。结果：Livin蛋白和Smac蛋白在BTCC组织中的阳性表达率分别73.8%（31/42）和28.6%（12/42），而在18例癌旁正常黏膜组织中分别为0和77.8%（14/18），两者在癌和癌旁间的表达差异均有统计学意义 (P＜0.01)；是否复发Livin蛋白和Smac蛋白在BTCC中的表达差异均有统计学意义(P＜0.05)，不同性别、年龄、组织学分级、临床分期、肿瘤数目Livin蛋白和Smac蛋白在BTCC中的表达差异均无统计学意义。Livin蛋白和Smac蛋白在BTCC组织中的表达呈负相关(rs=-0.462，P＜0.05)。结论：Livin蛋白高表达和Smac蛋白低表达或缺失表达可能是导致BTCC的发生及复发的原因，两者可能是BTCC细胞凋亡信号传导网络中的重要一环。

关键词: 膀胱移行细胞癌(BTCC), Livin, Smac, 细胞凋亡, 免疫组化

Abstract: Abstract Objective:To investigate the expression of Livin proteins and Smac proteins in the bladder transitional cell carcinoma (BTCC) and their correlation. Methods：The expression of Livin proteins and Smac proteins were assessed in 42 cases of the BTCC tissues and 18 cases of peritumorial normal mucosa tissue by SABC Immunohistochemistry,and their relationships with clinical pathological features were analyzed.Results:The expression of Livin proteins and Smac proteins in the BTCC were 73.8%(31/42) and 28.6%(12/42),while in 18 cases of peritumorial normal mucosa tissue,respectively, 0 and 77.8%(14/18).Significant differences of Livin proteins and Smac proteins expression were found between BTCC and peritumorial normal mucosa tissue groups(P＜0.01);and both were significantly correlated with recurrence(P＜0.05);but they didn’t correlate to sexualities, ages, histological grades, clinical stages, the number of tumors. And the expression levels of Livin proteins and Smac proteins showed a negative correlation in the BTCC (rs=-0.462, P＜0.05).Conclusion:The relatively high expression of Livin proteins and the low or not expression of Smac proteins may lead to the occurrence and recurrence of the BTCC, and both maybe play an important role in the cell apoptosis of the BTCC.

Key words: bladder transitional cell carcinoma (BTCC), Livin, Smac, apoptotic, Immunohistochemistry.