天津医药

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羟氯喹联合低分子肝素及糖皮质激素治疗妊娠合并抗磷脂综合征效果分析

齐莉1,王晓非2,张晓莉1   

  1. 1. 中国医科大学附属盛京医院
    2. 中国医科大学附属盛京医院风湿免疫科
  • 收稿日期:2013-12-16 修回日期:2014-06-12 出版日期:2014-10-15 发布日期:2014-10-15
  • 通讯作者: 齐莉

Clinical Analysis of Hydroxychloroquine Combined with Low-Molecular-Weight Heparin and Glucocorticoids in Treatment of Pregnant Women with Antiphospholipid Syndrome

QI Li ,WANG Xiao fei,ZHANG Xiao li   

  1. Department of Rheumatology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China
  • Received:2013-12-16 Revised:2014-06-12 Published:2014-10-15 Online:2014-10-15
  • Contact: QI Li

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摘要：

【摘要】目的 探讨羟氯喹联合低分子肝素及糖皮质激素治疗妊娠合并抗磷脂综合征的安全性和有效性。方法 回顾分析12 例妊娠合并抗磷脂综合征患者的临床资料，其中8 例结缔组织病继发抗磷脂综合征，4 例原发性抗磷脂综合征，均采用羟氯喹联合低分子肝素治疗，部分联合糖皮质激素治疗。结果 所有患者均顺利产下活婴，婴儿出生时无畸形，Apgar 评分良好，随访2~15 个月发育正常，产妇及婴儿均无不良事件发生。结论 羟氯喹联合低分子肝素及糖皮质激素治疗妊娠合并抗磷脂综合征安全有效，其临床应用价值仍需进一步研究证实。

关键词: 抗磷脂综合征, 羟氯喹, 肝素, 低分子, 妊娠

Abstract:

[Abstract] Objective  To investigate the safety and efficacy of hydroxychloroquine plus low-molecular-weight heparin and glucocorticoids in pregnant women with antiphospholipid syndrome (APS). Methods  Clinical data of 12 pregnant women with APS were retrospectively analyzed. Eight patients were APS secondary to connective tissue disease while four were primary APS. Hydroxychloroquine plus low-molecular-weight heparin was employed for the treatment of all the patients，among some of whom undergone combined glucocorticoids therapy. Results  All patients underwent a successful delivery with no abnormalities and are with normal Apgar scores of the babies. No compliations were developed during a follow up of 2-15 months. Conclusion  Hydroxychloroquine plus low-molecular-weight heparin and glucocorticoids is safe and effective in treatment of pregnant women with APS, but its clinical value needs further investigate

Key words: antiphospholipid syndrome, hydroxychloroquine, heparin, low-molecular-weight, pregnancy