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早期再灌注治疗对ST段抬高心肌梗死患者白细胞的影响

李舒承1,郝玉明2,郭金锐1,李春华1   

  1. 1. 承德医学院附属医院
    2. 河北医科大学第二医院
  • 收稿日期:2013-09-11 修回日期:2013-12-20 出版日期:2014-04-15 发布日期:2014-04-15
  • 通讯作者: 李舒承

Reperfusion Therapy and White Blood Cell Count in Patients with Acute Myocardial Infarction

  • Received:2013-09-11 Revised:2013-12-20 Published:2014-04-15 Online:2014-04-15
  • Contact: Li shu cheng

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摘要：

【摘要】目的 观察对于急性ST段抬高型心肌梗死(STEMI)早期再灌注治疗后外周血白细胞（WBC）计数与心脏事件的变化及两者的关系。方法 将151例发病3h内开始再灌注治疗的STEMI患者分成急诊经皮冠状动脉介入（PCI）治疗组52例（PCI组）和阿替普酶溶栓组99例（溶栓组），记录并比较2组发病4d内WBC与心脏事件变化。结果 PCI组治疗后2d、4d的WBC及心脏事件均低于溶栓组，差异有统计学意义（P<0.05），治疗后2d的WBC与心脏事件呈正相关（r=0.226，P<0.05）。结论 急诊PCI术后的WBC与心脏事件明显降低，STEMI后WBC升高程度与近期心脏事件相关。

关键词: 心肌梗死, 血管成形术, 经腔, 经皮冠状动脉, 心肌再灌注, 白细胞计数, 经皮冠状动脉介入, 溶栓治疗

Abstract:

[Abstract] Objective To study the relationship between blood cell count and cardiac events in acute ST elevation myocardial infarction patients treated with reperfusion in the early stage.Methods In this study, we assigned151patients to whom reperfusion therapy had been delivered within 3hours of STEMIsymptominto two groups: primary percutaneous cor? onary intervention group and thrombolysis therapy group. Differences of cardiac events and white blood cell count in these two groups were analyzed in the first 4days. Results In the second day and the forth day, cardiac events rate and white blood cell count were significantly lower in the primary percutaneous coronary intervention group than those in the thromboly? sis therapy group (P＜0.05). In the second day, white blood cell count has a positive correlation with cardiac events rate (r= 0.226,P＜0.05). Conclusion Primary percutaneous coronary intervention decreased blood cell count and cardiac events rate. In patients with acute myocardial infarction, increasing white blood cell was related to cardiac events in the near future.

Key words: myocardial infarction, angioplasty, transluminal, percutaneous coronary, myocardial reperfusion, leukocyte count, percutaneous coronary intervention, 溶栓治疗