天津医药

• 临床研究 • 上一篇    下一篇

Snail 和Raf激酶抑制蛋白在非小细胞肺癌侵袭转移中的作用

齐战1,杨大运2,高少伟3   

  1. 1. 河北 医科大学第四医院
    2. 河北医科大学第四医院
    3. 赵县人民医院
  • 收稿日期:2013-12-05 修回日期:2014-02-17 出版日期:2014-06-15 发布日期:2014-06-15
  • 通讯作者: 齐战

The Study on Expression of Snail and RKIP in non-small cell lung cancer invasion and metastasis.

  • Received:2013-12-05 Revised:2014-02-17 Published:2014-06-15 Online:2014-06-15

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摘要： 摘要：目的 检测非小细胞肺癌（non-small cell lung cancer,NSCLC）组织中Snail和RKIP(raf kinase inhibitor protein,RKIP)蛋白的表达情况，探讨两者与患者临床病理特征的关系。方法 采用免疫组织化学方法检测124例NSCLC及67例癌旁正常肺组织中Snail和RKIP蛋白的表达情况。结果 Snail蛋白在肺癌中高表达，表达率为79.03% (98/124)，RKIP在肺癌中低表达，表达率为36.29% (45/124)，两者的表达水均与肺癌的分化程度 、TNM分期、淋巴结转移及术后生存时间有明显关系；Snail与RKIP的蛋白表达水平呈负相关（P<0.05）。结论 Snail高表达与RKIP低表达可能是NSCLC侵袭转移的重要生物学标志。

关键词: 非小细胞肺癌, Snail, Raf激酶抑制蛋白

Abstract: Abstract： Objective To detect the expression of Snail and RKIP in NSCLC and its relationship with the clinicopathologic characteristics .Methods Immunohistochemical staining was used to detect Snail/RKIP expression in 124 cases of NSCLC and 67 cases of adjacent normal lung tissue .Results Immunohistochemistry revealed that of the 124 cases, there was a high expression of Snail and a low RKIP protein, 79.03% (98/124) and 36.29% (45/124) respectively. There was correlation of Snail and RKIP protein expression with the degree of differentiation of tumor 、TNM stage、 lymph node metastasis and the survival time（P<0.05, respectively）. Snail protein levels were negatively correlated with RKIP in lung carcinoma (P <0.05). Conclusion The overexpression of Snail and the low expression of RKIP might be important biological markers for invasion and metastasis of NSCLC.

Key words: NSCLC, Snail, raf kinase inhibitor protein