天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (10): 1183-1186.doi: 10.11958/j.issn.0253-9896.2015.10.026

• 应用研究 • 上一篇    下一篇

CA724、CA242及AFP在肝癌TACE治疗前后的表达变化及临床意义

  

  1. 1河北省沧州市中心医院消化内科(邮编 061001)， 2普外科
  • 收稿日期:2014-12-01 修回日期:2015-05-06 出版日期:2015-10-15 发布日期:2015-10-22

Analysis of the dynamic changes and clinic significance of serum CA724, CA242 and AFP#br# levels before and after TACE treatment of primary hepatic carcinoma

  1. 1 Department of Gastroenterology， Cangzhou Central Hospital， Cangzhou 061001， China; 2 Department of General Surgery，
    Cangzhou Central Hospital
  • Received:2014-12-01 Revised:2015-05-06 Published:2015-10-15 Online:2015-10-22

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摘要： 摘要： 目的 观察血清 CA724、 CA242 及甲胎蛋白(AFP)在原发性肝癌患者肝动脉化疗栓塞术（TACE）治疗前后
的变化及临床意义。方法 选取原发性肝癌患者 （原发性肝癌组） 45 例及健康对照者 （健康对照组） 40 例， 应用电化
学发光免疫分析法检测健康对照组及肝癌患者在 TACE 术前 2 d、 术后 1 周和 1 个月时血清 CA724、 CA242 及 AFP，
分析 3 个指标的相关性及与临床资料间的关系， 观察肝癌患者 AFP＜400 μg/L 与 AFP≥400 μg/L 组中血清 CA724、
CA242 在手术前后的变化。结果 原发性肝癌组术前血清 CA724、 CA242 及 AFP 含量均高于健康对照组（P <
0.05）， 血清 CA724、 AFP 阳性率高于健康对照组 （P < 0.01）。原发性肝癌组 AFP 在 TACE 治疗后 1 周及 1 个月均较
治疗前 2 d 降低（P < 0.01）， CA724 在治疗后 1 个月低于治疗前（P < 0.05）， 而 CA242 差异无统计学意义（P > 0.05）。
原发性肝癌患者血清 CA724 及 AFP 的表达与肿瘤大小有关（P < 0.05）。术后 1 个月， AFP＜400 μg/L 与 AFP≥400
μg/L 组 CA724 均较术前下降（P < 0.05）。CA724 与 AFP 的表达呈正相关（r =0.754， P < 0.05）。结论 血清 CA724
可作为协助评价肝癌 TACE 术后疗效的肿瘤标志物之一。

关键词: 肝肿瘤, 肿瘤, 多原发性, 甲胎蛋白类, CA724, CA242, 肝动脉化疗栓塞术

Abstract: Abstract: Objective To investigate the change of serum CA724, CA242 and AFP levels before and after transcatheter
artery chemoembolization (TACE) treatment of primary hepatic carcinoma（PHC）patients as well as its clinic significance.
Methods Patients of PHC (n=45) and healthy adults (n=40) were enrolled. Serum samples were collected from each healthy
people and PHC patients 2 days before TACE， l week and 1 month after TACE. Electrochemiluminescence Immunoassay (ECLI)
was used to determine serum CA724, CA242 and AFP levels, and correlations among three indexes as well as their relationships
with clinical data were also analysed., Change of serum CA724 and CA242 levels before and after TACE were compared in AFP <
400 μg/L group and AFP≥400 μg/L group. Results Serum levels of CA724, CA242 and AFP in PHC group were significantly
higher than that in healthy control groups before TACE therapy（P < 0.05） . Positive rates of serum CA724 and AFP were higher
in PHC group（P < 0.01） than that in healthy control group. AFP decreased significantly at both 1 week and 1 month upon TACE
treatment compared with that at before teratment（P < 0.01） . CA724 was significantly lower at one month after treatment than that
at before treatment（P < 0.05） . But there was no significant difference in CA242 before and after treatment（P > 0.05） . CA724
and AFP expressions are associated with tumor size（P < 0.05） . After one month of therapy, serum CA724 level was obviously
decreased in both AFP <400 μg/L and AFP≥400 μg/L groups. Before and after TACE therapy, there was a positive correlation
between the expression of AFP and CA724 （r=0.754， P < 0.05） . Conclusion Serum CA724 can be used as one of the tumor
markers to assist the evaluation of curative effect of TACE on PHC.

Key words: liver neoplasms, neoplasms, multiple primary, alpha-fetoproteins, CA724, CA242, TACE