天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (10): 1209-1212.doi: 10.11958/j.issn.0253-9896.2015.10.033

• 综述 • 上一篇    下一篇

血小板在炎性疾病中活化机制研究进展

  

  1. 1天津医科大学总医院耳鼻喉科 （邮编 300052）； 2医学检验科
  • 收稿日期:2015-02-28 修回日期:2015-07-20 出版日期:2015-10-15 发布日期:2015-10-22

Research of platelets activation during Inflammation

  1. 1 Department of Otolaryngology, Tianjin Medical University General Hospital, Tianjin 300052, China; 2 Medical Laboratory
  • Received:2015-02-28 Revised:2015-07-20 Published:2015-10-15 Online:2015-10-22

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摘要： 摘要： 血小板是具有止血功能的血细胞成分， 也是炎性病变的重要参与者。研究发现， 在脓毒症时， 血小板对白
细胞募集能力的增强及与之形成聚集体是促进炎性病变的重要因素， 而血小板数量减少往往与不良临床结局有
关。因此， 血小板试验在病情监测中的价值成为研究者们关注的问题。在侵入性真菌感染时， 血小板同时表达介导
抑菌效应和促进真菌传播效应， 从而使调控血小板和真菌之间相互作用变得困难。在过敏性炎症时， 血小板的过度
活化可加重气道障碍并导致肺功能改变。本文就血小板在炎性病变中活化机制的研究进展进行综述。

关键词: 血小板活化, 炎症, 脓毒症, 真菌, 哮喘, 综述

Abstract: Abstract: Platelets is the important hemostatic component in the blood and the critical participants in inflammation.
It is an important promoting factor during inflammation and can recruit leukocytes and aggregate in sepsis. Decreasing plate⁃
let count was correlated with reverse clinical outcome. Therefore, the value of the platelets examination in clinical monitor
was studied by many researchers. Under circumstance of fungal infections, platelets mediate antimicrobial activity and assist
dissemination of the fungi synchronously. Regulating interaction between platelets and fungi is difficult. In allergic inflamma⁃
tion patients, the excessive activating of platelets aggravates airway obstruction and worsen pulmonary function. We reviewed
current research in activating platelets during inflammation.

Key words: platelet activation, inflammation, sepsis, fungi, asthma, review