天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (10): 1213-1216.doi: 10.11958/j.issn.0253-9896.2015.10.034

• 综述 • 上一篇    

IL-23/IL-17 轴在强直性脊柱炎发病中的作用及治疗意义研究进展

  

  1. 1天津， 天津医院脊柱外科 （邮编 300233）； 2中国康复研究中心北京博爱医院
  • 收稿日期:2015-01-30 修回日期:2015-05-27 出版日期:2015-10-15 发布日期:2015-10-22

Roles of IL-23/IL-17 axis in pathogenesis and treatment of ankylosing spondylitis

  1. 1 Department of Spine Surgery, Tianjin Hospital, Tianjin 300233, China； 2 Beijing Bo Ai Hospital, China Rehabilitation
    Research Center
  • Received:2015-01-30 Revised:2015-05-27 Published:2015-10-15 Online:2015-10-22

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摘要： 摘要： 强直性脊柱炎（AS）发病机制至今不明， 治疗效果不佳。白细胞介素（IL） -23/IL-17 轴是近几年受到高度
重视的重要免疫通路。本文对 IL-23/IL-17 轴在 AS 发病遗传学和免疫学中的作用进行论述， 并介绍了抗 IL-23 和
抗 IL-17 抗体用于治疗 AS 的新进展。IL-23/IL-17 轴在 AS 发病和治疗中的重要作用提示其可能成为一个有效的
新治疗靶点。

关键词: 脊柱炎, 强直性, 白细胞介素 23 , 白细胞介素 17 , 免疫疗法 , 综述, IL-23/IL-17 轴

Abstract: Abstract: The treatments for ankylosing spondylitis (AS) are still not effective, which partially due to its unclear patho⁃
genesis. Interleukin (IL)-23/IL-17 axis is a significant immunologic pathway which has attracted much attention in the past
few years. This article reviewed the role of IL-23/IL-17 axis in genetic and immunological pathogenesis of AS, and intro⁃
duced the recent progresses in treatments of AS using anti-IL-23 or anti-IL-17 antibody. The important role of IL-23/IL-
17 axis in the pathogenesis and treatment of AS indicates its potential use as a new therapeutic target.

Key words: spondylitis, ankylosing, interleukin-23, interleukin-17, immunotherapy, review, IL-23/IL-17 axis