天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (8): 925-928.doi: 10.11958/j.issn.0253-9896.2015.08.026

• 诊断技术 • 上一篇    下一篇

原发性肝癌病理分化程度与超声造影表现的关系

刘建勇，周永和，李嘉，刘勇刚，陆伟   

  1. 天津市第二人民医院、天津市肝病医学研究所
  • 收稿日期:2015-04-13 修回日期:2015-04-30 出版日期:2015-08-15 发布日期:2015-08-15
  • 通讯作者: 周永和 E-mail:zhouyonghe@aliyun.com
  • 作者简介:刘建勇(1973)，男，本科，主要从事肝病诊疗及肝癌射频消融方面研究

Correlation of histopathologic grading of hepatocellular carcinoma with its contrast-enhanced ultrasound

LIU Jianyong, ZHOU Yonghe, LI Jia, LIU Yonggang, LU Wei   

  1. Tianjin Second People Hospital, Tianjin 300192, China
  • Received:2015-04-13 Revised:2015-04-30 Published:2015-08-15 Online:2015-08-15
  • Contact: Yong-He ZHOU E-mail:zhouyonghe@aliyun.com

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摘要： 目的评价原发性肝细胞癌（HCC）超声造影（CEUS）血供增强模式的显像特征，探讨HCC 组织学分化程度与CEUS 的关系。方法回顾术前应用SonoVue 超声造影剂的224 例259 个HCC 病灶CEUS 表现，将所获得曲线形态、灌注参数及灌注模式与标本的组织分化程度进行对照分析。结果不同分化程度HCC 始增时间差异无统计学意义（P＞0.05）；低分化组达峰、增强和始消时间出现均最早，其次为中分化组，高分化组最晚；低分化组增强时间和廓清时间均最短，其次为中分化组，高分化组最长，各组间比较差异有统计学意义（P＜0.01）。动脉相早期造影剂灌注模式分为蛛网样、放射样及混合样三类，高分化组以放射样为主28 例(47.14%），蛛网样最少7 例（14.29%）；低分化组大部分表现为蛛网样88 例（69.29%），只有6 例（4.73%）为放射样；中分化组大部分为混合样（49/83， 59.04%）。结论不同分化程度HCC 超声造影声学定量参数变化特征及动脉相灌注模式不同，CEUS 可作为评估 HCC 分化程度及生物学行为的可靠方法。

关键词: 癌, 肝细胞, 超声检查, 造影剂, 肿瘤分期, 血供灌注

Abstract: Objective To explore the correlation between the enhancement pattern of hepatocellular carcinoma (HCC) on contrast-enhanced ultrasound (CEUS) and its tumor differentiation on histopathology. Methods HCC lesions (n=259) from 224 patients were retrospectively evaluated with CEUS and histopathological examination. CEUS was performed with SonoVue. The characteristics of blood perfusion and parameters of the time-intensity curve (TIC) were analyzed by ACQ soft⁃ ware. Histopathological diagnoses were decided base on Edmonson grading system. Results Pathologic grading of HCC was not related to the arrival time（P＞0.05）；The washing-out time point and the enhancement time point and peak time point all appeared earlier in poorly differentiated HCC group, than those in moderately differentiated HCC group than those in well differentiated HCC group（P＜0.01）；The enhancement time point and the expurgation time point are shorter in poorly differ⁃ entiated HCC group than those in moderately differentiated HCC group than those in well differentiated HCC group. All dif⁃ ferences were with statistical significance. The mode of arterial perfusion in early stage was divided into 3 types: spider web type, radiative type and mixed type. The well differentiated HCC group mainly presented as radiative type (28/49, 47.14%）. But the most of poorly differentiated HCC group mainly present as spider web type（88/127, 69.29%）. The mix type was more common in moderately differentiated HCC group（49/83, 59.03%）. Conclusion CEUS show different features of TIC pa⁃ rameters and blood perfusion in different pathological stages of HCC lesions so it can serve as a method to assess the biologi⁃ cal behavior of hepatocellular carcinoma.

Key words: carcinoma, hepatocellular, ultrasonography, contrast media, neoplasm staging, blood perfusion