天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (10): 1247-1250.doi: 10.11958/20160361

• 临床研究 • 上一篇    下一篇

严重急性呼吸综合征患者十年生存质量分析

华静娜， 孙昕， 吴琦， 李莉， 邢志珩， 赵新骞   

  1. 天津市海河医院， 天津市呼吸疾病研究所（邮编 300350）
  • 收稿日期:2016-04-27 修回日期:2016-07-02 出版日期:2016-10-15 发布日期:2016-10-21
  • 通讯作者: 孙昕 E-mail:13302031999@126.com
  • 作者简介:华静娜（1980）， 女， 主治医师， 硕士， 主要从事呼吸及危重症研究
  • 基金资助:
    天津市卫生局科技基金项目（2014KY17）

Analysis of the quality of life in patients with severe acute respiratory syndrome for 10 years

HUA Jingna, SUN Xin, WU Qi， LI Li, XING Zhiheng, ZHAO Xinqian   

  1. Tianjin Haihe Hospital, Tianjin Institute of Respiratory Diseases, Tianjin 300350, China
  • Received:2016-04-27 Revised:2016-07-02 Published:2016-10-15 Online:2016-10-21
  • Contact: SUN Xin E-mail:13302031999@126.com

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摘要： 目的 对严重急性呼吸综合征（SARS）患者 10 年后的生存质量进行分析。 方法 收集确诊为 SARS 的患者 25 例为 SARS 组， 健康体检者 25 例为对照组， 2 组一般资料差异无统计学意义。 采用健康调查简表（SF-36）从生理机能、生理职能、躯体疼痛、一般健康状况、精力、社会功能、情感职能以及精神健康等 8 个方面对被调查者的生存质量进行评价。 比较 2 组肺功能指标， 包括用力肺活量（FVC）、一秒用力呼气容积（FEV1）、一秒率（FEV1/FVC）、肺总量（TLC）、残气容积（RV）、校正后一口气弥散量（TLCOc SB）及校正后弥散率（TLCOc/VA）； 并分析 SARS 组各肺功能指标与生存质量各维度评分的相关性。 骨 MRI 扫描检查 SARS 组患者髋关节与股骨头坏死情况。 结果 SARS 组中有 23 例（92.0%）生存质量总评分差， 2 例（8.0%）生存质量总评分中等。 SARS 组较对照组各维度生存质量评分偏低（P＜ 0.01）。 SARS 组仅 TLCOc SB 低于对照组， 生理机能评分与 FEV1、FEV1/FVC 呈正相关， 躯体疼痛评分与 FEV1/FVC 呈正相关（P＜ 0.05）， 其他生存质量评分与肺功能指标间均无相关性。 SARS 组中股骨头非坏死者 14 例（56%）、坏死者 11 例（44%）。 坏死组各维度生存质量仅生理机能得分低于非坏死组（P＜ 0.05）。 结论 SARS 患者的生存质量低下既有心理因素也有身体因素， SARS 患者的肺通气功能和股骨头坏死影响了患者的生存质量， 特别是生理机能。

关键词: 严重急性呼吸综合征, SARS 病毒, 呼吸功能试验, 预后, 股骨头坏死, 生存质量

Abstract: Objective To analyse the quality of life in patients with severe acute respiratory syndrome (SARS) for 10 years. Methods Twenty-five SARS patients were collected as SARS group and 25 healthy persons were used as control group. There were no significant differences in general clinical data between two groups. The quality of life of the respondents was evaluated by the MOS item short form health survey (SF- 36) including physiological function, physical pain, general health condition, energy, social function, emotional function and mental health. The pulmonary function indicators including forced vital capacity (FVC), one second forced expiratory volume (FEV1), one second rate (FEV1/FVC), total lung capacity (TLC), residual volume (RV), corrected breath diffusing capacity (TLCOc SB) and corrected dispersion rate TLCOc/VA were also compared between two groups. The correlation between each dimension score of pulmonary function indexes and quality of life were analyzed in SARS group. Data of hip and femoral head necrosis were detected by MRI scan in SARS group of patients. Results Total quality of life score was poor in 23 cases (92.0%), and moderate quality of life score in 2 cases (8.0%). The quality of life score was lower in SARS group than that of control group (P < 0.01). Data of TLCOc SB was lower in SARS group than that of control group. The score of physiological function was positively correlated with FEV1 and FEV1/FVC. The score of physical pain was positively correlated with FEV1/FVC (P＜ 0.05). There were no significant differences between quality of life score and pulmonary function indicators. There were 11 cases (44% ) of avascular necrosis of femoral head, and 14 cases (56%) of non-avascular necrosis of femoral head in SARS group. The score of physiological function was lower in femoral head necrosis group than that of non necrosis group (P＜ 0.05). Conclusion The lower quality of life in patients with SARS is not only related with psychological factors but also related with physical factors. The damage of pulmonary function and (or) necrosis of femoral head affect the quality of life in patients with SARS, especially the physiological function.

Key words: severe acute respiratory syndrome, SARS virus, respiratory function tests, prognosis, femur head necrosis；, qualityoflife