天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (4): 401-404.doi: 10.11958/20150195

• 专题研究-乳腺肿瘤 • 上一篇    下一篇

有氧运动对乳腺癌化疗患者癌因性疲乏的影响及相关机制

曹玉瑶1 ， 宋祎1 ， 陈凤敏1 ， 徐锦江2△   

  1. 1 辽宁医学院研究生院 （邮编 121000）； 2 辽宁医学院附属第一医院
  • 收稿日期:2015-09-25 修回日期:2015-12-04 出版日期:2016-04-15 发布日期:2016-05-20
  • 通讯作者: △通迅作者 E-mail： ll1h_xjj@126.com E-mail:xujinjiang1971@sina.com
  • 作者简介:曹玉瑶 （1990）， 女， 硕士在读， 主要从事肿瘤护理研究
  • 基金资助:
    辽宁省科技厅课题 （2013225305）

Effects and related mechanisms of aerobic exercise on cancer-related fatigue in breast cancer patients undergoing chemotherapy

CAO Yuyao1 ， SONG Yi 1 , CHEN Fengmin1 , XU Jinjiang2△   

  1. 1 Graduate School, Liaoning Medical University, Jinzhou 121000, China; 2 Nursing Department, the First Affiliated Hospital of Liaoning Medical University
  • Received:2015-09-25 Revised:2015-12-04 Published:2016-04-15 Online:2016-05-20
  • Contact: △Corresponding Author E-mail： ll1h_xjj@126.com E-mail:xujinjiang1971@sina.com

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摘要： 摘要： 目的 探讨有氧运动对乳腺癌化疗患者癌因性疲乏的影响及相关机制。方法 60 例根治术术后欲进行化疗的乳腺癌患者随机分为运动组和对照组， 各 30 例。对照组给予常规护理。运动组除常规护理外， 在化疗第 1 天开始有氧运动干预， 直到化疗结束。使用 Piper 疲乏修订量表 （RPFS） 对疲乏程度进行评估。分别在化疗前、 化疗结束和化疗后 4 周检测两组患者的血红蛋白 （Hb） 水平、 最大摄氧量 （VO2max ） 和 RPFS 得分情况。结果 两组 Hb 水平在化疗前、 化疗结束和化疗后 4 周差异均无统计学意义 （P＞0.05）； 化疗结束和化疗后 4 周， 两组 Hb 水平均低于化疗前 （P＜0.05）。化疗前两组 VO2max 和 RPFS 得分差异无统计学意义 （P＞0.05）； 化疗结束和化疗后 4 周， 运动组 VO2max 和 RPFS 得分与化疗前相比差异均无统计学意义 （P＞0.05）， 对照组 VO2max 低于化疗前水平， RPFS 得分高于化疗前水平 （均 P＜0.05）。结论 化疗期间有氧运动能够有效缓解化疗导致癌因性疲乏加重的情况， 这可能与有氧运动能对抗 VO 降低有关。

关键词: 疲劳, 肿瘤, 体育和训练, 血红蛋白类, 氧耗量, 癌因性疲乏, 有氧运动, 最大摄氧量, Piper 疲乏量表

Abstract: Abstract： Objective To investigate the effects of aerobic exercise during chemotherapy on cancer-related fatigue in breast cancer patients, and related mechanism thereof. Methods Sixty breast cancer patients who underwent radical surgery were randomly assigned to exercise group and control group, 30 patients for each group. Patients in exercise group received regular nursing care plus aerobic exercise during chemotherapy, while patients in control group only received regular nursing care. The revised Piper fatigue scale (RPFS) was used to assess the fatigue degree. Values of hemoglobin concentration(Hb), maximal oxygen uptake (VO2max) and RPFS scores were detected before chemotherapy, at the end of chemotherapy and 4 weeks after chemotherapy, respectively. Results There was no significant difference in Hb concentration before chemotherapy, at the end of chemotherapy and 4 weeks after chemotherapy between two groups (P＞0.05). The level of Hb was significantly lower at the end of chemotherapy and 4 weeks after chemotherapy than that before chemotherapy in two groups (P＜0.05). There were no significant differences in VO2max and RPFS score before chemotherapy between two groups (P＞0.05). At the end of chemotherapy and 4 weeks after chemotherapy, there were no significant differences in VO2max and RPFS scores than those before chemotherapy in exercise group (P＞0.05). In control group, value of VO2max was significantly lower at the end of chemotherapy and 4 weeks after chemotherapy than that before chemotherapy (P＜0.05), RPFS score was significantly higher than that before chemotherapy (P＜0.05). Conclusion Aerobic exercise during chemotherapy can be effectively against cancer-related fatigue, which may be related to the inhibitory effect of aerobic exercise on debasement of VO2max.

Key words: fatigue, neoplasms, physical education and training, hemoglobins, oxygen consumption, cancer-related fatigue, aerobic exercise, VO2max, Piper fatigue scale