关键词: 癫痫, 额叶, 脑电描记术, 工作记忆, 多通道脑电, theta 振荡, 能量密度

Abstract: Objective To investigate the characteristic of theta oscillation in patients with frontal lobe epilepsy (FLE) by the analysis of multi-channel electroencephalographs (EEGs) during rest state and working memory(WM) maintenance. Methods The 19 FLE patients and 17 healthy subjects underwent EEG recording with 34-channel EEG machine during visual working memory task performance. The differences of behavioral results were analyzed between FLE group and controls. Short-time Fourier transform was used to calculate the power spectral density of different frequency bands in 34 channels. The theta power values during the retention period of working memory and rest state were compared between two groups. Results Compared with controls, reaction time of FLE increased significantly (P < 0.01) and accuracy decreased (P < 0.05). The power spectral density of theta band for FLE increased both in Fz and frontal region during rest state (P < 0.01). Compared with controls, the power spectral density of theta oscillation decreased significantly in the frontal region for FLE during WM maintenance. Conclusion Our results suggest that working memory in patients with FLE was impaired. The absence of theta oscillation during the WM delayde period may provide a possible neural mechanism for the working memory dysfunction in FLE.

Key words: epilepsy, frontal lobe, electroencephalography, working memory, multi- channel electroencephalographs, theta oscillation, power spectral density