天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (10): 1107-1111.doi: 10.11958/20182217

• 综述 • 上一篇    下一篇

CD326在恶性肿瘤中的研究现状及应用前景

周静 1，丁文文 1，朱宇熹 2△   

  1. 1荆楚理工学院医学院基础医学教研室（邮编448000）；2重庆医科大学附属第一医院肿瘤科
  • 收稿日期:2019-01-03 修回日期:2019-07-30 出版日期:2019-10-15 发布日期:2019-11-11
  • 通讯作者: 周静 E-mail:zhoujing6162@163.com
  • 基金资助:
    湖北省高等学校优秀中青年科技创新团队项目;荆门市科技局2018年科研项目

The current research status and application prospects of CD326 in malignant tumors

ZHOU Jing1, DING Wen-wen1, ZHU Yu-xi2△   

  1. 1 Medical College of Jingchu Technology University, Jingmen 448000, China; 2 Department of Oncology, the First Affiliated Hospital of Chongqing Medical University
  • Received:2019-01-03 Revised:2019-07-30 Published:2019-10-15 Online:2019-11-11
  • Supported by:
     

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摘要： 摘要：CD326是一种跨膜蛋白，既表达于部分正常上皮细胞，参与人体胚胎形成以及成体细胞的分化；也表达于 上皮源性癌细胞，在肿瘤的形成与扩散中发挥着不可忽视的作用。CD326自被发现以来，其在各类常见恶性肿瘤中 的表达及意义、作用机制、诊疗应用等方面备受关注。本文分别从CD326的结构特点、与肿瘤微环境的关系、在正常 干细胞及肿瘤细胞中的表达及意义、临床应用等方面进行阐述，以更深入研究肿瘤相关分子的应用价值。

关键词: CD326, 恶性肿瘤, 综述

Abstract: Abstract: CD326 is a transmembrane protein, which is expressed in some normal epithelial cells and participates in the formation of human embryo and the differentiation of the adult cells. Also CD326 is expressed in the epithelial carcinoma cells and plays an important role in the formation and spread of tumors. Since its discovery, CD326 has attracted much attention in the expression, significance, mechanism, diagnosis and treatment in various common malignant tumors. This paper discussed the structure feature of CD326, the relationship between CD326 and the tumor microenvironment, the significance of CD326 expression in normal stem cells and tumor cells, and the clinic application, in order to further study the application value of tumor-related molecules.

Key words: CD326, malignant tumor, review

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