天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (11): 1166-1169.doi: 10.11958/20191195

• 临床研究 • 上一篇    下一篇

支原体肺炎患儿的肺功能改变特点及其危险因素分析

张海军，董晓蕾，蔺萃，房有福，张洪玉   

  1. 1山东省潍坊市益都中心医院儿内科（邮编262500）；2山东省青州市中医院妇科
  • 收稿日期:2019-04-19 修回日期:2019-09-05 出版日期:2019-11-15 发布日期:2019-12-17
  • 通讯作者: 张海军 E-mail:ggg1256@163.com

Characteristics and risk factors of pulmonary function changes in children with mycoplasma pneumoniae pneumonia

ZHANG Hai-jun,DONG Xiao-lei,LIN Cui,FANG You-fu,ZHANG Hong-yu   

  1. 1 Department of Pediatric, Yidu Central Hospital of Weifang, Qingzhou 262500, China;2 Department of Gynaecology, Chinese Medicine Hospital in Qingzhou City
  • Received:2019-04-19 Revised:2019-09-05 Published:2019-11-15 Online:2019-12-17

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摘要： 目的 总结支原体肺炎（MPP）患儿肺功能改变的不同类型及特点，寻找肺功能改变的危险因素。方法 选取2017年7月—2018年12月期间确诊为MPP的住院患儿230例，根据是否发生肺功能改变将患儿分为异常组（50例，包括通气功能障碍38例，肺弥散功能异常12例）和正常组（180例）。分析异常组患儿肺功能改变的类型及特点，比较 2组患儿的基本情况、临床表现、肺功能变化及相关辅助检查。结果 异常组在住院时间、发热时间、呼吸音减低比例及C反应蛋白（CRP）、乳酸脱氢酶（LDH）等方面均高于正常组（P＜0.05）。二分类Logistic回归结果显示，发热 （OR=2.276，95%CI：1.658～3.125）和住院（OR=1.976，95%CI：1.478～2.642）时间延长、CRP 升高（OR=1.112，95%CI：1.056～1.170）是 MPP发生肺功能改变的危险因素。结论 MPP患儿肺功能改变以通气障碍为主，但也存在一部分弥散功能障碍；长期发热、住院时间延长及急性期CRP升高是导致MPP患儿肺功能改变的高危因素。

关键词: 肺炎, 支原体, 儿童, 通气不足, 危险因素, 肺功能

Abstract: Objective We summarized the different types and characteristics of pulmonary function changes in children with mycoplasma pneumoniae pneumonia (MPP), and look for risk factors for changes in lung function. Methods A total of 230 children with MPP hospitalized between July 2017 and December 2018 were selected in this study. The children were divided into abnormal group (n=50, there were 38 cases of ventilation disorders and 12 cases of diffusion disorders) and normal group (n=180) according to whether pulmonary function changes occurred. The types and characteristics of pulmonary function changes in abnormal group were analyzed, and the differences of basic conditions,clinical manifestations, changes of pulmonary function and related auxiliary examinations were compared between the two groups. Results There were significantly longer values in hospitalization time, fever time, proportion of hypopnea, Creactive protein (CRP) and lactatedehydrogenase (LDH) in abnormal group than that of normal group (P＜0.05). The Logistic regression analysis showed that extended heating time (OR=2.276, 95%CI: 1.658-3.125), extended hospitalization time (OR=1.976, 95%CI: 1.478-2.642), and CRP elevation (OR=1.112, 95%CI: 1.056-1.170) were the risk factors of pulmonary function changes in MPP (P＜0.05).Conclusion The main pulmonary function changes in MPP children are ventilation disorders, but there are also some diffusion disorders. Long-term fever, prolonged course of disease and increased CRP in acute stage are the high risk factors leading to pulmonary function changes in MPP children.

Key words: pneumonia, mycoplasma, child, hypoventilation, risk factors, pulmonary function