天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (8): 869-873.doi: 10.11958/20190699

• 综述 • 上一篇    下一篇

非协调-5同源物家族成员在肿瘤发生发展过程中生物学功能及临床应用价值研究进展

董冬，周云丽△   

  1. 天津医科大学肿瘤医院，天津市癌症临床研究中心，国家癌症临床研究中心，癌症预防与治疗重点实验室（邮编300060）
  • 收稿日期:2019-03-13 修回日期:2019-04-03 出版日期:2019-08-15 发布日期:2019-08-16
  • 通讯作者: 周云丽 E-mail:zhouyunli_911@yahoo.com
  • 作者简介:董冬（1985），男，讲师，博士，主要从事肿瘤发生发展的机制研究
  • 基金资助:
    UNC5D抑制肾癌转移的作用及其机制研究

Advances in research on biological functions and clinical application values of UNC5 homolog family members during tumorigenesis and development

DONG Dong, ZHOU Yun-li△   

  1. Tianjin Medical University Cancer Institute and Hospital, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin 300060, China
  • Received:2019-03-13 Revised:2019-04-03 Published:2019-08-15 Online:2019-08-16

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摘要： 摘要：非协调-5（UNC5）同源物家族成员是经典神经生长因子-1（Netrin-1）的重要受体，除了参与调节神经系统 的发育外，在其他多种领域，尤其是在肿瘤发生发展的过程中，同样发挥着重要的调控作用。该家族成员在多种肿 瘤组织中表达下调，而且都具有“依赖性受体”的属性，即在配体Netrin-1缺失的条件下，这些成员也具有诱导细胞凋 亡的能力。然而，除了这些共性的特征外，该家族各成员又都具有自身的特性，并以各自独特的方式发挥着抑癌作 用。本文将对此家族成员在肿瘤发生发展中的作用做一综述，并着重阐述成员间的共性和个性特征以及临床应用 方面的新发现。

关键词: UNC5同源物家族, Netrin-1, 肿瘤, 生物学功能, 临床应用

Abstract: Abstract: Members of the UNC5 homolog family are important receptors for the classical nerve growth-directing factor-1 (Netrin-1). In addition to participating in the development of the nervous system, they also play important roles in many other fields, especially in tumorigenesis. Members of this family are down-regulated in a variety of tumor tissues, and all have a "dependent receptor" property, that is, in the absence of ligand Netrin-1, these members have the ability to induce apoptosis. However, in addition to these common features, each member of the family has its own characteristics, and plays an unique role to participate in tumor suppression. This article will review the role of these family membersin tumorigenesis and development, and emphasis is placed on the commonality and personality of those members as well as the new findings in clinical applications

Key words: UNC5 homolog, Netrin-1, tumor, biological function, clinical applications