天津医药

天津医药 ›› 2020, Vol. 48 ›› Issue (8): 753-756.doi: 10.11958/20201160

• 临床研究 • 上一篇    下一篇

新型冠状病毒肺炎患者血清胱抑素C与炎性因子水平变化及其相关性#br#

刘浩，龙利△，张继波，金晟，余建峰，覃慧群，徐敏   

  1. 江汉大学附属湖北省第三人民医院肾内科（邮编430000）
  • 收稿日期:2020-04-26 修回日期:2020-05-05 出版日期:2020-08-15 发布日期:2020-08-12
  • 通讯作者: 龙利 E-mail:68335589@qq.com
  • 作者简介:刘浩（1991），男，硕士，住院医师，主要从事肾脏疾病的基础与临床研究

Changes and correlation of serum cystatin C and inflammatory factors in patients with novel coronavirus infected pneumonia

LIU Hao, LONG Li△, ZHANG Ji-bo, JIN Sheng, YU Jian-feng, QIN Hui-qun, XU Min   

  1. Department of Nephrology, the Third People’s Hospital of Hubei Province Affiliated to Jianghan University,
     Wuhan 430000, China
  • Received:2020-04-26 Revised:2020-05-05 Published:2020-08-15 Online:2020-08-12
  • Contact: LONG Li E-mail:68335589@qq.com

PDF (PC)

5036

摘要： 目的　观察新型冠状病毒肺炎（COVID-19）患者血清胱抑素C（CysC）与炎性因子水平的变化，并分析其相关性。方法　选择2020年1月—4月江汉大学附属湖北省第三人民医院收治的成人COVID-19患者152例，根据《新型冠状病毒肺炎诊疗方案（试行第七版）》中的临床分型标准将其分为普通型组（n=110）和重型组（n=42）。采用全自动生化分析仪检测血清CysC、血肌酐（Scr）、尿素氮（BUN）、C反应蛋白（CRP）水平，采用酶联免疫吸附试验（ELISA）检测血清白细胞介素（IL）-6、血清淀粉样蛋白A（SAA）水平。采用Pearson相关分析2组患者血清CysC、Scr、BUN水平与IL-6、CRP、SAA水平的相关性。结果　重型组患者血清CysC水平及升高者比例均高于普通型组（均P＜0.05）；2组患者Scr、BUN水平及升高者比例差异均无统计学意义。重型组患者血清CRP、IL-6和SAA水平均高于普通型患者（P＜0.05）。重型组患者血清CysC、Scr、BUN水平与IL-6（r分别为0.647、0.376、0.364）、CRP（r分别为0.579、0.374、0.351）、SAA（r分别为0.524、0.338、0.305）水平均呈正相关（均P＜0.05）；普通型组患者血清CysC、Scr、BUN水平与IL-6（r分别为0.615、0.384、0.357）、CRP（r分别为0.517、0.345、0.323）、SAA（r分别为0.491、0.314、0.328）水平均呈正相关（均P＜0.05）。结论　COVID-19重型患者血清CysC与炎性因子水平均较普通型患者高，炎性因子水平升高可能是COVID-19患者肾损伤的机制之一。

关键词: 冠状病毒属, 肺炎, 病毒性, 新型冠状病毒肺炎, 胱抑素C, 炎性因子

Abstract: Objective　To observe the changes of serum cystatin C (CysC) and inflammatory factors in patients with coronavirus disease 2019 (COVID-19), and to explore their relationship. Methods　One hundred and fifty-two adult patients with COVID-19 admitted to the Third People’s Hospital of Hubei Province Affiliated to Jianghan University from January to April 2020 were selected in this study. Patients were divided into common group (n = 110) and severe group (n = 42) according to the clinical classification criteria in the "New Coronavirus Pneumonia Diagnosis and Treatment Program Seventh Edition". The serum levels of CysC, creatinine (Scr), urea nitrogen (BUN), and C-reactive protein (CRP) were detected by an automatic biochemical analyzer. Serum levels of interleukin 6 (IL-6) and amyloid A (SAA) were detected by enzyme-linked immunosorbent assay (ELISA). The correlation between serum levels of CysC, Scr, BUN, IL-6, CRP and SAA were compared between the two groups by Pearson correlation analysis. Results The serum level of CysC and the proportion of patients with increased CysC levels were both significantly higher in severe group than those of common group (P＜0.05). There were no significant differences in the serum levels of  Scr and BUN and the proportions of patients with increased levels between the two groups. The serum levels of CRP, IL-6 and SAA were significantly higher in the severe group than those in the common group (P＜0.05). In the severe group, the serum levels of CysC, Scr and BUN were positively correlated with IL-6 (r=0.647, 0.376 and 0.364, respectively), CRP (r=0.579, 0.374 and 0.351, respectively) and SAA (r=0.524, 0.338 and 0.305, respectively, all P＜0.05). In the common group the serum levels of  CysC, Scr and BUN were positively correlated with IL-6(r=0.615, 0.384 and 0.357, respectively), CRP (r=0.517, 0.345 and 0.323, respectively) and SAA (r=0.491, 0.314 and 0.328, respectively, all P＜0.05). Conclusion　The serum levels of cystatin C and inflammatory factors are higher in COVID-19 severe patients than those in common patients. The elevated levels of inflammatory factors may be one of the mechanisms of kidney injury in COVID-19 patients. 

Key words: coronavirus, pneumonia, viral, coronavirus disease 2019, cystatin C, inflammatory factors

中图分类号: