天津医药

天津医药 ›› 2021, Vol. 49 ›› Issue (7): 773-777.doi: 10.11958/20210539

• 综述 • 上一篇    下一篇

Notch信号通路在肝纤维化中的研究进展

张望，万义鹏，朱萱   

  1. 南昌大学第一附属医院消化内科（邮编330006）
  • 收稿日期:2021-03-04 修回日期:2021-04-05 出版日期:2021-07-15 发布日期:2021-07-12
  • 作者简介:张望（1991），男，博士在读，主要从事肝纤维化的基础与临床研究。E-mail：ndzhangwang@163.com
  • 基金资助:
    国家自然科学基金地区科学基金项目（81960120）

Research progress of Notch signaling pathway in liver fibrosis

ZHANG Wang, WAN Yi-peng, ZHU Xuan   

  1. Department of Digestive Diseases, the First Affiliated Hospital, Nanchang University, Nanchang 330006, China
  • Received:2021-03-04 Revised:2021-04-05 Published:2021-07-15 Online:2021-07-12

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摘要： 肝纤维化是肝脏对各种慢性损伤因素的一种修复反应，持续进展的肝纤维化可导致肝硬化，甚至肝癌。目前研究表明肝纤维化是可逆的。众多信号通路参与肝纤维化的发生发展，其中Notch信号通路在肝纤维化的发病机制中发挥重要作用，本文就Notch信号通路在肝纤维化中的研究进展作一综述。

关键词: 肝星状细胞, 肝细胞, 巨噬细胞, 受体, Notch, 肝硬化, Notch信号通路, 肝窦内皮细胞

Abstract: Hepatic fibrosis is considered as a kind of repair response of liver to various chronic injury factors. Progressive liver fibrosis can lead to the development of cirrhosis and even hepatocellular carcinoma. Current researches have indicated that liver fibrosis is reversible. Several signaling pathways are involved in the occurrence and development of liver fibrosis, among which Notch signaling pathway plays a critical role in liver fibrogenesis. In this paper, the research progress of Notch signaling pathway in liver fibrogenesis is reviewed.

Key words: hepatic stellate cells, hepatocytes, macrophages, receptors, Notch, liver cirrhosis, Notch signaling pathway, liver sinusoidal endothelial cells