天津医药

天津医药 ›› 2022, Vol. 50 ›› Issue (5): 552-556.doi: 10.11958/20211591

• 综述 • 上一篇    下一篇

APC-EPCR-PAR1通路在类风湿关节炎中的研究进展

刘轩绮1，2，刘汇洋1，2，赵京洋1，3，尹芳蕊1，2，3，白力1，2，3，王永福1，2，3△   

  1. 1包头医学院第一附属医院风湿免疫科，包头医学院风湿免疫研究所（邮编014000）；2内蒙古科技大学包头医学院；3内蒙古自治区自体免疫学重点实验室
  • 收稿日期:2021-07-08 修回日期:2021-11-05 出版日期:2022-05-15 发布日期:2022-07-04
  • 基金资助:
    内蒙古自治区自然科学基金资助项目（2020LH08001，2021BS08006)

Research progress of APC-EPCR-PAR1 pathway in rheumatoid arthritis

LIU Xuanqi1, 2, LIU Huiyang1, 2, ZHAO Jingyang1, 3, YIN Fangrui1, 2, 3, BAI Li1, 2, 3, WANG Yongfu1, 2, 3△   

  1. 1 Department of Rheumatology and Immunology, the First Affiliated Hospital of Baotou Medical College (Institute of Rheumatology and Immunology, Baotou Medical College), Baotou 014000, China; 2 Baotou Medical College, Inner Mongolia University of Science and Technology; 3 Inner Mongolia Autoimmune Key Laboratory
  • Received:2021-07-08 Revised:2021-11-05 Published:2022-05-15 Online:2022-07-04

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摘要： 类风湿关节炎（RA）是一种慢性、系统性自身免疫性疾病。活化蛋白C（APC）是由其前体蛋白C（PC）转化而来的一种天然抗凝血剂，在凝血调控中起着关键的作用。APC可与内皮蛋白C受体（EPCR）结合，激活内皮细胞上的蛋白激酶受体1（PAR1），从而启动细胞的保护和抗炎反应。现就APC-EPCR-PAR1活化通路上各靶点在RA中的研究进展进行综述，探讨APC-EPCR-PAR1通路在RA疾病中的潜在治疗价值，为RA的治疗提供更多的选择。

关键词: 关节炎, 类风湿；蛋白质C；受体, 细胞表面；蛋白酪氨酸激酶类；APC-EPCR-PAR1通路

Abstract: Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease. Activated protein C (APC) is a natural anticoagulant transformed from its precursor protein C (PC), which plays a key role in the regulation of blood coagulation. APC can bind to endothelial protein C receptor (EPCR) and activate protein kinase receptor 1 (PAR1) on endothelial cells, thereby initiating cell protection and anti-inflammatory response. This article summarizes the research progress of each target on the APC-EPCR-PAR1 activation pathway in RA, discusses the potential therapeutic value of APC-EPCR-PAR1 pathway in RA diseases, and provides more options for the treatment of RA in the future.

Key words: arthritis, rheumatoid, protein C, receptors, cell surface, protein-tyrosine kinases, APC-EPCR-PAR1 pathway

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