天津医药

天津医药 ›› 2026, Vol. 54 ›› Issue (9): 948-951.doi: 10.11958/20260370

• 临床研究 • 上一篇    下一篇

胃肠充盈超声造影对妊娠期女性胃十二指肠疾病的诊断价值

鲁南楠(), 刘昕, 舒红艳, 沈翠△()   

  1. 湖北省黄石市妇幼保健院超声影像科（邮编 435000）
  • 收稿日期:2026-02-02 修回日期:2026-03-20 出版日期:2026-09-15 发布日期:2026-09-14
  • 通讯作者: △E-mail：49130751@qq.com
  • 作者简介:鲁南楠（1986），女，主治医师，主要从事妇产超声及胃肠超声造影方面研究。E-mail：406369173@qq.com
  • 基金资助:
    湖北省自然科学基金项目(2025AFD021)

Diagnostic value of gastrointestinal filling contrast-enhanced ultrasound for gastroduodenal diseases in pregnant women

LU Nannan(), LIU Xin, SHU Hongyan, SHEN Cui△()   

  1. Department of Ultrasound Imaging, Huangshi Maternal and Child Health Care Hospital, Huangshi 435000, China
  • Received:2026-02-02 Revised:2026-03-20 Published:2026-09-15 Online:2026-09-14
  • Contact: △E-mail：49130751@qq.com

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摘要：

目的 评估胃肠充盈超声造影在妊娠期女性胃十二指肠疾病中的诊断价值，并与胃镜结果进行比较。方法 选取因上消化道症状就诊的妊娠患者144例，分为早中孕组（孕周≤28周，93例）和晚孕组（孕周>28周，51例）。所有患者均接受胃肠充盈超声造影及胃镜检查。以胃镜结果为金标准，计算超声造影诊断的敏感度、特异度、准确度、阳性预测值（PPV）、阴性预测值（NPV）、阳性似然比（+LR）及阴性似然比（-LR），比较2组诊断效能差异，并采用配对卡方检验比较2种检查方法的病变整体检出率。结果 胃肠超声造影整体诊断敏感度为90.15%，特异度为66.67%，准确度为88.19%，PPV为96.75%，NPV为38.10%，+LR为2.70，-LR为0.15。早中孕组的敏感度（93.02% vs. 84.78%）、特异度（71.43% vs. 60.00%）及准确度（91.40% vs. 82.35%）均高于晚孕组。胃镜整体检出率为91.67%（132/144），与超声造影的85.42%（123/144）差异无统计学意义（P=0.052）。患者对胃肠超声造影的耐受性显著优于胃镜（VAS评分：1.49±1.12 vs. 4.67±1.66，t=17.511，P<0.01）。结论 胃肠充盈超声造影可作为妊娠期胃十二指肠疾病筛查及诊断的重要无创辅助手段，尤其在早中孕期，其诊断效能更佳。

关键词: 妊娠, 胃疾病, 十二指肠疾病, 胃镜检查, 胃肠充盈超声造影

Abstract:

Objective To evaluate the diagnostic value of gastrointestinal filling contrast-enhanced ultrasound (GIC-US) for gastroduodenal diseases in pregnant women, and to compare it with the result of gastroscopy. Methods A total of 144 pregnant women with upper gastrointestinal symptoms were enrolled and divided into the early-mid pregnancy group (gestational age ≤28 weeks, n=93) and the late pregnancy group (gestational age >28 weeks, n=51). All patients underwent both GIC-US and gastroscopy. Using the result of gastroscopy as the reference standard, sensitivity, specificity, accuracy, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (+LR), and negative likelihood ratio (-LR) of GIC-US were calculated. The diagnostic performance between the two groups was compared, and the McNemar test was used to analyze the difference in detection rates between the two methods. Results The overall sensitivity, specificity, accuracy, PPV and NPV of GIC-US were 90.15%, 66.67%, 88.19%, 96.75% and 38.10%, respectively, with a+LR of 2.70 and a -LR of 0.15. The early-mid pregnancy group showed higher sensitivity (93.02% vs. 84.78%), specificity (71.43% vs. 60.00%) and accuracy (91.40% vs. 82.35%) compared with those of the late pregnancy group. The overall detection rate of gastroscopy was 91.67% (132/144) compared with 85.42% (123/144) for contrast-enhanced ultrasound, showing no statistically significant difference (P=0.052). The tolerance of patients to GIC-US was significantly better than that of gastroscopy (VAS score: 1.49±1.12 vs. 4.67±1.66, P<0.01). Conclusion GIC-US can serve as an important non-invasive auxiliary method for the screening and diagnosis of gastroduodenal diseases during pregnancy, with better diagnostic performance, particularly in the early-to-mid trimester.

Key words: pregnancy, stomach diseases, duodenal diseases, gastroscopy, gastrointestinal filling contrast-enhanced ultrasound

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