circRNA作用于急性缺血性脑卒中的研究进展

doi:10.11958/20220671

天津医药 ›› 2022, Vol. 50 ›› Issue (12): 1335-1339.doi: 10.11958/20220671

circRNA作用于急性缺血性脑卒中的研究进展

郑继青¹(), 龙耀斌¹^,^△(), 刘云²

1 广西医科大学第二附属医院康复医学科（邮编530007）
2 广西医科大学第一附属医院骨科

收稿日期:2022-05-05 修回日期:2022-06-06 出版日期:2022-12-15 发布日期:2022-12-30
通讯作者: 龙耀斌 E-mail:zhengjiqing@sr.gxmu.edu.cn;long232316@163.com
作者简介:郑继青（1996），女，初级治疗师，主要从事神经系统疾病机制与康复方面研究。E-mail：zhengjiqing@sr.gxmu.edu.cn
基金资助:
国家自然科学基金资助项目(81960768);广西自然科学基金项目(2022GXNSFAA035511);广西壮族自治区医疗卫生重点学科建设项(桂卫科教发〔2022〕4号)

Research advance on circRNA in acute ischemic stroke

ZHENG Jiqing¹(), LONG Yaobin¹^,^△(), LIU Yun²

1 Department of Rehabilitation, the Second Affiliated Hospital, Guangxi Medical University, Nanning 530007, China
2 Department of Orthopedics, the First Affiliated Hospital of Guangxi Medical University

Received:2022-05-05 Revised:2022-06-06 Published:2022-12-15 Online:2022-12-30
Contact: LONG Yaobin E-mail:zhengjiqing@sr.gxmu.edu.cn;long232316@163.com

郑继青, 龙耀斌, 刘云. circRNA作用于急性缺血性脑卒中的研究进展[J]. 天津医药, 2022, 50(12): 1335-1339.

ZHENG Jiqing, LONG Yaobin, LIU Yun. Research advance on circRNA in acute ischemic stroke[J]. Tianjin Medical Journal, 2022, 50(12): 1335-1339.

摘要/Abstract

摘要：

环状RNA（circRNA）介导内源性竞争RNA（ceRNA）调控网络已经被证实在急性缺血性脑卒中（AIS）损伤后的病理和生理过程中发挥关键作用，且分子诊断工具广泛应用后发现circRNA有望成为AIS的生物标志物，对上述研究进行归纳，可拓宽对AIS发生发展机制的研究视野，为其诊断和治疗提供新思路。

关键词: 卒中, 脑缺血, RNA，环状, 生物标志物, 内源性竞争RNA

Abstract:

In recent years, circularRNA (circRNA) mediated endogenous competitive RNA (ceRNA) regulatory network has been proved to play a key role in pathological and physiological processes following acute ischemic stroke (AIS) injury. Moreover, circRNA is expected to be a biomarker of AIS after the wide application of molecular diagnostic tools. The summary of the above studies can broaden the vision of the pathogenesis of AIS and provide new ideas for its diagnosis and treatment.

Key words: stroke, brain ischemia, RNA, circular, biomarkers, competing endogenous RNA

中图分类号:

R743.3

参考文献 47

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circRNA作用于急性缺血性脑卒中的研究进展

Research advance on circRNA in acute ischemic stroke

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