细胞自噬在急性呼吸窘迫综合征中的研究进展

doi:10.11958/20221782

天津医药 ›› 2023, Vol. 51 ›› Issue (6): 668-672.doi: 10.11958/20221782

• 综述 • 上一篇

细胞自噬在急性呼吸窘迫综合征中的研究进展

黄承军¹(), 徐宇¹, 秘乐¹, 王秀军¹, 刘振峰², 王红嫚¹^,^△

1 遵义医科大学第五附属（珠海）医院呼吸与危重症医学科（邮编519100）
2 遵义市红花岗区人民医院呼吸与危重症医学科

收稿日期:2022-11-07 修回日期:2023-02-17 出版日期:2023-06-15 发布日期:2023-06-20
通讯作者: ^△E-mail：2496453591@qq.com
作者简介:黄承军（1990），男，硕士在读，主要从事呼吸危重症急救方面研究。E-mail：1534240828@qq.com
基金资助:
国家自然科学基金资助项目(81960023);贵州省卫生健康委科学技术基金项目(gzwkj2021-093)

Research progress of autophagy in acute respiratory distress syndrome

HUANG Chengjun¹(), XU Yu¹, MI Le¹, WANG Xiujun¹, LIU Zhenfeng², WANG Hongman¹^,^△

1 Department of Respiratory and Critical Care Medicine, the Fifth Affiliated(Zhuhai) Hospital of Zunyi Medical University, Zhuhai 519100, China
2 Department of Respiratory and Critical Care Medicine, People' Hospital of Honghuagang District

Received:2022-11-07 Revised:2023-02-17 Published:2023-06-15 Online:2023-06-20
Contact: ^△E-mail：2496453591@qq.com

黄承军, 徐宇, 秘乐, 王秀军, 刘振峰, 王红嫚. 细胞自噬在急性呼吸窘迫综合征中的研究进展[J]. 天津医药, 2023, 51(6): 668-672.

HUANG Chengjun, XU Yu, MI Le, WANG Xiujun, LIU Zhenfeng, WANG Hongman. Research progress of autophagy in acute respiratory distress syndrome[J]. Tianjin Medical Journal, 2023, 51(6): 668-672.

摘要/Abstract

摘要：

急性呼吸窘迫综合征（ARDS）是一类以失控的炎症反应为核心的呼吸系统临床综合征。自噬作为维持细胞稳态的主要途径，对ARDS炎症反应具有重要调节作用。在动物或细胞实验中证实，药物干预调控雷帕霉素靶蛋白、腺苷酸活化蛋白激酶等信号通路的转导，从而调节细胞自噬可减轻肺损伤。因此，调节细胞自噬可能成为ARDS患者重要的治疗方法。现就自噬的发生机制以及肺泡巨噬细胞、中性粒细胞、肺泡上皮细胞和血管内皮细胞自噬在ARDS中的作用进行综述，以期为ARDS的诊治、自噬调节剂的研发和临床应用提供参考。

关键词: 自噬, 呼吸窘迫综合征, 信号通路, 内质网应激

Abstract:

Acute respiratory distress syndrome (ARDS) is a type of respiratory clinical syndrome centered on uncontrolled inflammatory response. As a major pathway to maintain cellular homeostasis, autophagy plays an important regulatory role in the inflammatory response in ARDS. In animal or cellular experiments, it has been confirmed that drug intervention regulates the transduction of signaling pathways such as target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK), thereby regulating autophagy to reduce lung injury. Therefore, regulating autophagy may become an important treatment for ARDS patients. This article reviews the mechanism of autophagy and the role of autophagy in ARDS in alveolar macrophages, neutrophils, alveolar epithelial cells and vascular endothelial cells, in order to provide new reference for the diagnosis and treatment of ARDS, the research and development of autophagy modulators and clinical application.

Key words: autophagy, respiratory distress syndrome, signaling pathway, endoplasmic reticulum stress

中图分类号:

R563.9

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细胞自噬在急性呼吸窘迫综合征中的研究进展

Research progress of autophagy in acute respiratory distress syndrome

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