天津医药

天津医药 ›› 2025, Vol. 53 ›› Issue (11): 1175-1179.doi: 10.11958/20251691

• 临床研究 • 上一篇    下一篇

血清MIF、25（OH）D与前庭性偏头痛患者认知功能的相关性

金霄1(), 王艳红2△(), 杨连琦2, 张东2, 李勇2, 任志华2, 王彩虹2   

  1. 1 承德市中心医院高压氧治疗室（邮编067000）
    2 神经内科
  • 收稿日期:2025-05-08 修回日期:2025-07-16 出版日期:2025-11-15 发布日期:2025-11-19
  • 通讯作者: △E-mail: wyh18203142366@126.com
  • 作者简介:金霄（1990），女，主治医师，主要从事高压氧治疗相关疾病方面研究。E-mail：jin13020890980@163.com
  • 基金资助:
    承德市科技计划项目(202204A012)

Correlation between serum MIF, 25(OH)D and cognitive function in patients with vestibular migraine

JIN Xiao1(), WANG Yanhong2△(), YANG Lianqi2, ZHANG Dong2, LI Yong2, REN Zhihua2, WANG Caihong2   

  1. 1 Hyperbaric Oxygen Therapy Room
    2 Department of Neurology, Chengde Central Hospital, Chengde 067000, China
  • Received:2025-05-08 Revised:2025-07-16 Published:2025-11-15 Online:2025-11-19
  • Contact: △E-mail: wyh18203142366@126.com

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摘要：

目的 探究血清巨噬细胞游走抑制因子（MIF）、25羟维生素D[25（OH）D]与前庭性偏头痛（VM）患者认知功能的相关性。方法 选取200例VM患者为VM组，依据蒙特利尔认知评估标准（MoCA）将患者分为认知正常组（128例）及认知障碍组（72例），另选200例健康体检者为对照组。采用酶联免疫吸附试验检测血清MIF、25（OH）D水平；多因素Logistic回归分析VM患者发生认知障碍的影响因素；采用受试者工作特征（ROC）曲线分析血清MIF、 25（OH）D水平诊断VM患者认知障碍的价值。结果 VM组患者血清MIF水平高于对照组，血清25（OH）D水平低于对照组（P<0.05）；认知障碍组患者血清MIF水平高于认知正常组，血清25（OH）D水平低于认知正常组（P<0.05）。多因素Logistic回归分析显示，血清MIF水平升高、25（OH）D水平降低是VM患者发生认知障碍的独立危险因素（P<0.05）。ROC曲线分析显示，血清MIF、25（OH）D水平联合诊断VM患者认知障碍的曲线下面积[AUC（95%CI）]为0.900（0.850~0.938），高于MIF[0.797（0.735~0.851）]和25（OH）D[0.817（0.756~0.868）]单独诊断（P<0.05）。结论 发生认知障碍的VM患者血清MIF水平升高，25（OH）D水平降低，二者联合诊断VM患者认知障碍的价值较高。

关键词: 偏头痛, 巨噬细胞游走抑制因子, 认知功能障碍, 25羟维生素D, 前庭性偏头痛

Abstract:

Objective To explore the correlation between serum macrophage migration inhibitory factor (MIF), 25-hydroxyvitamin D [25(OH)D] and cognitive function in patients with vestibular migraine (VM). Methods A total of 200 patients with VM were selected and used as the VM group. Based on the Montreal Cognitive Assessment (MoCA) criteria, patients were divided into the cognitively normal group (128 cases) and the cognitively impaired group (72 cases). Additionally, 200 healthy individuals undergoing routine health examination were selected as the control group. Serum MIF and 25(OH)D levels were measured using enzyme-linked immunosorbent assay. Multivariate Logistic regression was used to analyze influencing factors of cognitive impairment in VM patients. The value of serum MIF and 25(OH)D levels in diagnosing cognitive impairment in patients with VM was analyzed by using the receiver operating characteristic (ROC) curve. Results The serum MIF was higher in the VM group than that of the control group, and serum 25(OH)D was lower in the VM group (P<0.05). The serum MIF was higher in the cognitive impairment group than that of the cognitive normal group, while the serum 25(OH)D was lower in the cognitive impairment group than that of the cognitive normal group (P<0.05). Multivariate Logistic regression found that increased serum MIF level and decreased 25(OH)D level were independent risk factors for cognitive impairment in VM patients (P<0.05). ROC curve analysis showed that the AUC (95%CI) of the combined diagnosis of cognitive impairment in VM patients using serum MIF and 25(OH)D levels was 0.900 (0.850-0.938), which was higher than that of MIF diagnosed alone [0.797 (0.735-0.851)] and 25(OH)D alone [0.817 (0.756-0.868), P<0.05]. Conclusion VM patients with cognitive impairment have elevated serum MIF levels and decreased 25(OH)D levels. The combined diagnostic value of the two markers has a relatively high value for VM patients with cognitive impairment.

Key words: migraine, macrophage migration-inhibitory factors, cognitive dysfunction, 25-hydroxyvitamin D, vestibular migraine

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