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血管内皮生长因子在子宫腺肌病患者内膜-肌层界面的表达

刘志敏,刘素巧   

  1. 河北省石家庄市第二医院病理科
  • 收稿日期:2012-11-16 修回日期:2013-03-06 出版日期:2013-09-15 发布日期:2013-09-15
  • 通讯作者: 刘志敏

Expression of VEGF in the Endometrial-Myometrial Interface of Adenomyosis

  • Received:2012-11-16 Revised:2013-03-06 Published:2013-09-15 Online:2013-09-15

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摘要： 目的：探讨血管内皮生长因子（VEGF）在子宫腺肌病患者内膜-肌层界面的表达。方法：采用免疫组织化学方法对40例子宫腺肌病（实验组）和40例子宫肌瘤（对照组）患者的宫内膜-肌层界面及远肌层进行组织标记及分析。结果：VEGF在腺肌病组EMI处的表达：增殖期VEGF的表达强度高于远肌层，差异具有显著性（P〈0.01）；分泌期VEGF的表达亦高于远肌层，差异有统计学意义（p〈0.05）。对照组VEGF在增殖期的表达强度显示EMI处高于远肌层，差异显著（p〈0.05）；分泌期时两部位未见明显差异。组间比较EMI处VEGF的表达：腺肌病组在增生期和分泌期VEGF的表达均明显高于对照组，有统计学意义（p〈0.05）。结论：VEGF在子宫内膜-肌层界面的高表达可能与腺肌病的发生密切相关。

关键词: 子宫内膜, 子宫肌层, 子宫内膜异位症, 血管内皮生长因子类

Abstract: Objective:To observe the expression of VEGF in the endometrial-myometrial interface of adenomyosis.Methods:Immunohistochemistry SP method was adopted to determine the expression of VEGF in EMI of twenty cases of adenomyosis and of twenty cases of control subjects.Results:In adenomyosis group the expression level of VEGF was higher in EMI versus outer layer in the whole menstrual cycle (p<0.05).Between the groups, the expression level of VEGF was higher in EMI of adenomyosis group than that of control group in the whole menstrual cycle(p<0.05).Conclusion:The higher expression of VEGF in EMI is closely related to the pathogenesis of adenomyosis possibly.