天津医药

• 心血管疾病研究 • 上一篇    下一篇

天津地区汉族人群炎症细胞因子基因多态性与冠脉支架术后再狭窄的关系

高静   

  1. 天津市胸科医院
  • 收稿日期:2010-10-13 修回日期:2010-11-01 出版日期:2011-01-15 发布日期:2011-01-15
  • 通讯作者: 高静

Relationship of Inflammatory cytokines gene polymorphism with restenosis after percutaneous coronary intervention in Tianjin population

  • Received:2010-10-13 Revised:2010-11-01 Published:2011-01-15 Online:2011-01-15

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摘要： 目的 探讨中国天津地区汉族人群多个炎症细胞因子白细胞介素-6（IL-6）-572C/G、白细胞介素-1β (IL-1β) -511 C/T及白细胞介素-10（IL-10）-592C/A基因多态性 对经皮冠状动脉介入治疗（PCI）术后再狭窄的发病影响。 方法 对437例接受PCI并进行冠脉造影随访的患者，按冠脉造影结果分为再狭窄组（166例）和非再狭窄组（271例），运用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法检测IL-6 启动子（-572）、IL-1β启动子（-511）及IL-10启动子（-592）位点基因型和等位基因频率的分布。 结果 1. IL-6 -572C/G、 IL-1β -511 C/T及IL-10 -592C/A基因型和等位基因频率在再狭窄组和非再狭窄组之间差异无统计学意义（P均>0.05）；2. 再狭窄危险的多因素Logistic回归分析显示：Lp(a)、ACS 、术前狭窄程度、靶病变长度与ISR呈正相关（OR值分别为=1.90、3.92、2.07和3.04），参照血管直径、支架直径与ISR呈负相关（OR值分别为=0.76、0.39）。 结论 ：IL-6 -572C/G、 IL-1β -511 C/T及IL-10 -592C/A基因多态性与中国天津地区汉族人群再狭窄的发病无关。

关键词: 支架内再狭窄, 白细胞介素, 多态性现象（遗传学）, 基因

Abstract: 【Abstract】 Objective To investigate the relationship of inflammatory cytokines gene polymorphism with restenosis after percutaneous coronary Intervention(PCI) in Tianjin Chinese-Han population. Methods 437 patients who successfully underwent PCI with a follow-up angiography were divided into a restenosis group (166) and non-restenosis group (271). IL-6 polymorphism (-572C/G)、IL-1β polymorphism (-511C/T) and IL-10 polymorphism (-592C/A) in promoter region were genotyped respectively by restricted fragment length polymorphism using polymerase chain reaction (PCR-RFLP) method. Results (1) There were no significant difference in frequencies of IL-6-572 、IL-1β-511 and IL-10-592 genotype and allele between 2 groups (P>0.05); (2) Logistic regression analysis revealed postive correlations between Lp(a)、ACS patients、pre-PCI degree of stenosis、length of target lesion stenosis and restenosis （OR=1.90、3.92、2.07、3.04, respectively）; and there were negative correlations between the stent diameter, the diameter of reference vessel before stent implantation and restenosis（OR=0.76、0.39, respectively）. Conclusion (1)The polymorphism of IL-6 -572 C/G、IL-1β-511 C/T and IL-10 -592 C/A gene was not associated with restenosis in the Tianjin Chinese-Han population

Key words: Restenosis, Interleukin, Polymorphism(genetics), Gene